Background Surgical occlusion of the left atrial appendage has been hypothesized to
prevent ischemic stroke in patients with atrial fibrillation, but this has not been proved. The …

Background Antithrombotic therapy in valvular disease is important to mitigate thromboembolism,
but the hemorrhagic risk imposed must be considered. Methods The methods of this …

Background Cardiopulmonary bypass initiates a systemic inflammatory response syndrome
that is associated with postoperative morbidity and mortality. Steroids suppress inflammatory …

Background The effect of a restrictive versus liberal red-cell transfusion strategy on clinical
outcomes in patients undergoing cardiac surgery remains unclear. Methods In this multicenter…

Background The relative benefits and risks of performing coronary-artery bypass grafting (CABG)
with a beating-heart technique (off-pump CABG), as compared with cardiopulmonary …

Background Atrial fibrillation is a common post‐operative complication of cardiac surgery and
is associated with an increased risk of post‐operative stroke, increased length of intensive …

We sought to establish the efficacy and safety of prophylactic steroids in adult patients
undergoing cardiopulmonary bypass (CPB). We performed a meta-analysis of randomized trials …

Background Previously, we reported that there was no significant difference at 30 days in
the rate of a primary composite outcome of death, myocardial infarction, stroke, or new renal …

Background Perioperative bleeding is common in patients undergoing noncardiac surgery.
Tranexamic acid is an antifibrinolytic drug that may safely decrease such bleeding. Methods …

Background We reported previously that, in patients undergoing cardiac surgery who were at
moderate-to-high risk for death, a restrictive transfusion strategy was noninferior to a liberal …