Tissue damage leads to loss of cellular and mitochondrial membrane integrity and release
of damage-associated molecular patterns, including those of mitochondrial origin (mitoDAMPs…

Type 1 diabetes is an autoimmune and increasingly prevalent condition caused by immunological
destruction of beta cells. Insulin remains the mainstay of therapy. Endeavours in islet …

Background Optimizing engraftment and early survival after clinical islet transplantation is
critical to long-term function, but there are no reliable, quantifiable measures to assess beta …

Clinical islet transplantation has become an established treatment modality for selected
patients with type 1 diabetes. However, a large proportion of transplanted islets is lost through …

Ex vivo normothermic machine perfusion (NMP) preserves donor organs and permits real-time
assessment of allograft health, but the most effective indicators of graft viability are …

Islet transplantation is a well-established therapeutic treatment for a subset of patients with
complicated type I diabetes mellitus. Prior to the Edmonton Protocol, only 9% of the 267 islet …

The optimal endocrine transplant that should follow a successful kidney transplant in patients
with type 1 diabetes is currently open to debate. Ideally, a combined kidney and pancreas …

… Reversal of diabetes was defined as two consecutive readings <11.1 mmol/L (in accordance
with the American Diabetes Association) and maintained until study … Boris Gala-Lopez …

… day mortality (Table 4), the Gala-Lopez score consistently (3 of 4 patients) … Gala-Lopez
scoring system but only as being intermediate risk in the DNS (Table 5). We found the Gala-Lopez …

Human islet transplantation has been hampered by donor cell death associated with the
islet preparation procedure before transplantation. Regulated necrosis pathways are …