Some of the most common symptoms of the inflammatory bowel diseases (IBD, which include
ulcerative colitis and Crohn’s disease) are abdominal pain, diarrhea, and weight loss. It is …

Background— Alagille syndrome (AGS) is a dominantly inherited multisystem disorder
involving the liver, heart, eyes, face, and skeleton, caused by mutations in Jagged1. Intracranial …

Once considered rare in pedatric practice, chronic inflammatory bowel disease (IBD) is now
being recognized with increasing frequency in children of all ages. In fact, 25% to 30% of all …

The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common
causes of morbidity in children and young adults in the western world. Here we report the …

Alagille syndrome is an autosomal dominant disorder characterized by abnormal development
of liver, heart, skeleton, eye, face and, less frequently, kidney. Analyses of many patients …

Alagille syndrome (AGS) is an autosomal-dominant disorder characterized by intrahepatic
cholestasis and abnormalities of heart, eye and vertebrae, as well as a characteristic facial …

Alagille syndrome (AGS) is caused by mutations in the gene for the Notch signaling pathway
ligand Jagged1 (JAG1), which are found in 94% of patients. To identify the cause of …

We have studied 92 patients with Alagille syndrome (AGS) to determine the frequency of
clinical manifestations and to correlate the clinical findings with outcome. Liver biopsy …

Previous genome-wide association (GWA) studies typically focus on single-locus analysis,
which may not have the power to detect the majority of genuinely associated loci. Here, we …

Inflammatory bowel disease (IBD) is a common inflammatory disorder with complex etiology
that involves both genetic and environmental triggers, including but not limited to defects in …