The immunobiology of the innate response to Toxoplasma gondii

CM Miller, NR Boulter, RJ Ikin, NC Smith - International journal for …, 2009 - Elsevier
Toxoplasma gondii is a unique intracellular parasite. It can infect a variety of cells in virtually
all warm-blooded animals. It has a worldwide distribution and, overall, around one-third of …

A selective review of advances in coccidiosis research

…, D Blake, A Gruber, M Jenkins, NC Smith… - Advances in …, 2013 - Elsevier
Coccidiosis is a widespread and economically significant disease of livestock caused by
protozoan parasites of the genus Eimeria. This disease is worldwide in occurrence and costs …

Chasing the golden egg: vaccination against poultry coccidiosis

PA Sharman, NC Smith, MG Wallach… - Parasite …, 2010 - Wiley Online Library
Eimeria species, of the Phylum Apicomplexa, cause the disease coccidiosis in poultry,
resulting in severe economic losses every year. Transmission of the disease is via the faecal‐oral …

[HTML][HTML] Control of human toxoplasmosis

NC Smith, C Goulart, JA Hayward, A Kupz… - International Journal for …, 2021 - Elsevier
Toxoplasmosis is caused by Toxoplasma gondii, an apicomplexan parasite that is able to
infect any nucleated cell in any warm-blooded animal. Toxoplasma gondii infects around 2 …

The coccidian oocyst: a tough nut to crack!

SI Belli, NC Smith, DJP Ferguson - Trends in parasitology, 2006 - cell.com
Coccidian parasites are transmitted between hosts by the ingestion of food or water
contaminated with oocysts, followed by the release of infectious sporozoites and invasion of the …

[HTML][HTML] Oocyst wall formation and composition in coccidian parasites

…, SI Belli, DJP Ferguson, NC Smith - Memorias do Instituto …, 2009 - SciELO Brasil
The oocyst wall of coccidian parasites is a robust structure that is resistant to a variety of
environmental and chemical insults. This resilience allows oocysts to survive for long periods, …

[HTML][HTML] The Role of the P2X7 Receptor in Infectious Diseases

…, MP Lees, BM Saunders, JS Wiley, NC Smith - PLoS …, 2011 - journals.plos.org
ATP is an extracellular signal for the immune system, particularly during an inflammatory
response. It is sensed by the P2X 7 receptor, the expression of which is upregulated by pro-…

P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

…, JM Blackwell, JS Wiley, NC Smith - The journal of …, 2010 - journals.aai.org
The P2X 7 R is highly expressed on the macrophage cell surface, and activation of infected
cells by extracellular ATP has been shown to kill intracellular bacteria and parasites. …

[HTML][HTML] An experimental genetically attenuated live vaccine to prevent transmission of Toxoplasma gondii by cats

…, ME Grigg, AB Hehl, P Deplazes, NC Smith - Scientific reports, 2019 - nature.com
Almost any warm-blooded creature can be an intermediate host for Toxoplasma gondii.
However, sexual reproduction of T. gondii occurs only in felids, wherein fertilisation of haploid …

Eimeria maxima gametocyte antigens: potential use in a subunit maternal vaccine against coccidiosis in chickens

M Wallach, NC Smith, M Petracca, CMD Miller, J Eckert… - Vaccine, 1995 - Elsevier
Affinity-purified gametocyte antigens (APGA) from Eimeria maxima, emulsified in Freund's
adjuvant, were injected intramuscularly into breeding hens on two or three occasions. As a …