Background— Sirolimus reduces acute rejection in renal transplant recipients and prevents
vasculopathy in nonhuman primates and in-stent restenosis in humans. Its effects on …

Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile
dysfunction. Genetic mutations involving genes that encode cytoskeletal, sarcomere, and …

Aims Angiotensin converting enzyme (ACE) 2 catalyses the cleavage of angiotensin (Ang) I
to Ang 1‐9 and of Ang II to Ang 1‐7. ACE2 deficiency impairs cardiac contractility and …

Although primary graft dysfunction (PGD) is fairly common early after cardiac transplant,
standardized schemes for diagnosis and treatment remain contentious. Most major cardiac …

… variation of the quadrupole splitting [data taken from Macdonald and Seelig (1987a,b); cf. …
& Seelig, 1984; Borle & Seelig,1985; Macdonald & Seelig, 1987a,b). The relative change in the …

Background The selective cardiac myosin activator omecamtiv mecarbil has been shown to
improve cardiac function in patients with heart failure with a reduced ejection fraction. Its …

PURPOSE: The purpose of this systematic review was to address the treatment of multiligament
knee injuries, specifically (1) surgical versus nonoperative treatment, (2) repair versus …

Background: Persistent anterolateral rotatory laxity after anterior cruciate ligament (ACL)
reconstruction (ACLR) has been correlated with poor clinical outcomes and graft failure. …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end-…

A transthoracic echocardiogram is recommended in patients with suspected heart failure, to
improve diagnostic accuracy, and in patients with a new diagnosis of heart failure, to assess …