PT  - JOURNAL ARTICLE
AU  - Pasieka, Janice L.
AU  - Hershfield, Noel
TI  - Pancreatic polypeptide hyperplasia causing watery diarrhea syndrome: a case report
DP  - 1999 Feb 01
TA  - Canadian Journal of Surgery
PG  - 55--58
VI  - 42
IP  - 1
4099  - http://canjsurg.ca/content/42/1/55.short
4100  - http://canjsurg.ca/content/42/1/55.full
SO  - CAN J SURG1999 Feb 01; 42
AB  - Neuroendocrine tumours of the pancreas can secrete numerous peptides, leading to various recognizable clinical syndromes. The secretion of pancreatic polypeptide has been used as a marker for neuroendocrine tumours but is considered to be a biologically inert peptide. A 37-year-old woman had watery diarrhea syndrome from pancreatic polypeptide hyperplasia. Only 2 other reported cases in the literature have described pancreatic polypeptide hyperplasia; however, this is the first reported case in which the patient was successfully treated by surgical resection, with a 2-year follow-up. This report and review of the literature illustrate that pancreatic polypeptide hypersecretion may present as a clinical endocrinopathy.