RT Journal Article
SR Electronic
T1 The effect of octreotide on postoperative adhesion formation
JF Canadian Journal of Surgery
JO CAN J SURG
FD Canadian Medical Association
SP 43
OP 47
VO 43
IS 1
A1 Ataç Baykal
A1 Abdullah Ozdemir
A1 Nurten Renda
A1 Atilla Korkmaz
A1 Iskender Sayek
YR 2000
UL http://canjsurg.ca/content/43/1/43.abstract
AB Objective: To investigate the effect of octreotide, a long-acting analogue of somatostatin, on postoperative adhesion formation, because somatostatin inhibits secretion of some growth factors that have modulatory effects on collagen synthesis.Design: An experimental study.Setting: Surgical Research and Biochemistry laboratories at Hacettepe University, Ankara, Turkey.Subjects: Male Swiss albino mice.Interventions: Both sides of a 5-cm ileal segment from Swiss albino mice were scraped 10 times, and transient ischemia was induced by clamping the segmental artery. Animals were injected subcutaneously with 1 mL/d of saline for 3 days (group 1), a single 5-mL intraperitoneal dose of saline (group 2), subcutaneously with 10 μg/kg daily of octreotide for 3 days (group 3) or a single 10 μg/kg intraperitoneal dose of octreotide (group 4). In half of the animals repeat laparotomy was performed on postoperative day 5. After adhesions were graded, the scraped ileal segments were excised for determination of hydroxyproline quantity. The same procedure was repeated on postoperative day 14 for the remaining animals.Outcome measures: Adhesion grading, hydroxyproline levels.Results: On postoperative day 5, the intraperitoneal octreotide group (group 4) had a significantly lower median adhesion score than groups 1 and 2. On postoperative day 14, both octreotide groups (3 and 4) had a significantly lower median adhesion grading than both saline groups (1 and 2). Hydroxyproline levels of the groups were not significantly different on either day 5 or day 14.Conclusion: Octreotide has a beneficial effect in decreasing adhesion formation in the early postoperative period.