RT Journal Article
SR Electronic
T1 Review of the molecular profile and modern prognostic markers for gastric lymphoma: How do they affect clinical practice?
JF Canadian Journal of Surgery
JO CAN J SURG
FD Canadian Medical Association
SP 117
OP 124
DO 10.1503/cjs.002310
VO 55
IS 2
A1 Alevizos, Leonidas
A1 Gomatos, Ilias P.
A1 Smparounis, Spyridon
A1 Konstadoulakis, Manousos M.
A1 Zografos, Georgios
YR 2012
UL http://canjsurg.ca/content/55/2/117.abstract
AB Primary gastric lymphoma is a rare cancer of the stomach with an indeterminate prognosis. Recently, a series of molecular prognostic markers has been introduced to better describe this clinical entity. This review describes the clinical importance of several oncogenes, apoptotic genes and chromosomal mutations in the initiation and progress of primary non-Hodgkin gastric lymphoma and their effect on patient survival. We also outline the prognostic clinical importance of certain cellular adhesion molecules, such as ICAM and PECAM-1, in patients with gastric lymphoma, and we analyze the correlation of these molecules with apoptosis, angiogenesis, tumour growth and metastatic potential. We also focus on the host–immune response and the impact of Helicobacter pylori infection on gastric lymphoma development and progression. Finally, we explore the therapeutic methods currently available for gastric lymphoma, comparing the traditional invasive approach with more recent conservative options, and we stress the importance of the application of novel molecular markers in clinical practice.