TY - JOUR T1 - Treatment of an infected total hip replacement with the PROSTALAC system JF - Canadian Journal of Surgery JO - CAN J SURG SP - 24 LP - 28 VL - 50 IS - 1 AU - Angela Scharfenberger AU - Marcia Clark AU - Guy Lavoie AU - Greg O’Connor AU - Edward Masson AU - Lauren A. Beaupre Y1 - 2007/02/01 UR - http://canjsurg.ca/content/50/1/24.abstract N2 - Introduction: Infection after total hip replacement (THR) is a serious medical complication with significant negative ramifications for both the patient and the health care system. The prosthesis of antibiotic-loaded acrylic cement (PROSTALAC) was designed to treat the joint infection while maintaining functional movement in the hip.Methods: We identified 28 patients treated for infected THR with the PROSTALAC system, by retrospective chart review. Preoperative and intraoperative cultures were taken to identify the causative organism. After PROSTALAC insertion, patients underwent at least 6 weeks of intravenous (IV) antibiotics. Prior to undergoing post-treatment cultures, patients were required to be antibiotic-free for a minimum of 6 weeks, with normal laboratory values. We defined resolution infection as retention of a joint prosthesis for a minimum of 2 years.Results: Infection was identified in 28 patients in either the joint aspirate or intraoperative cultures. Of these patients, 2 failed to clear infection, requiring repeat PROSTALAC insertion. Two additional patients had positive 48-hour cultures post-second stage, treated with additional IV antibiotics. Retention of the post-PROSTALAC prosthesis is 100% at 2 years.Conclusion: PROSTALAC has acceptable infection resolution outcomes and appears effective for treating infected THR. ER -