PT  - JOURNAL ARTICLE
AU  - Hamad Alsubaie
AU  - Carly Leggett
AU  - Pascal Lambert
AU  - Jason Park
AU  - David Hochman
AU  - Debrah Wirtzfeld
AU  - Andrew McKay
TI  - Diagnosis of VTE postdischarge for major abdominal and pelvic oncologic surgery: implications for a change in practice
AID  - 10.1503/cjs.012314
DP  - 2015 Oct 01
TA  - Canadian Journal of Surgery
PG  - 305--311
VI  - 58
IP  - 5
4099  - http://canjsurg.ca/content/58/5/305.short
4100  - http://canjsurg.ca/content/58/5/305.full
SO  - CAN J SURG2015 Oct 01; 58
AB  - Background: Extended thromboprophylaxis after hospital discharge following cancer surgery has been shown to reduce the incidence of venous thromboembolism (VTE); however, this practice has not been universally adopted. We conducted a population-based analysis to determine the proportion of patients with symptomatic VTE diagnosed within 90 days after initial discharge following major abdominopelvic cancer surgery who might have benefited from extended thromboprophylaxis.Methods: We used the Manitoba Cancer Registry to identify patients who underwent major abdominopelvic cancer surgery between 2004 and 2009. The proportion in whom VTE was diagnosed during the initial hospital stay was determined by accessing the Hospital Separations Abstracts. The proportion in whom VTE was diagnosed after discharge was determined by examining repeat admissions within 90 days and by accessing Drug Programs Information Network records for newly prescribed anticoagulants. Detailed tumour and treatment-specific data allowed calculation of VTE predictors.Results: Of 6612 patients identified, 106 (1.60%) had VTE diagnosed during the initial stay and 96 (1.45%) presented with VTE after discharge. Among patients in whom VTE developed after discharge, 33.3% had a pulmonary embolus, 24% had deep vein thrombosis, and 6.3% had both. Predictors of presenting with VTE after discharge within 90 days of surgery included advanced disease, presence of other complications, increased hospital resource utilization, primary tumours of noncolorectal gastrointestinal origin and age younger than 45 years. The development of VTE was an independent predictor of decreased 5-year overall survival.Conclusion: The cumulative incidence of VTE within 90 days of major abdominopelvic oncologic surgery was 3.01%, with about half (1.45%) having been diagnosed within 90 days after discharge.