TY - JOUR T1 - Can we reduce ischemic cholangiopathy rates in donation after cardiac death liver transplantation after 10 years of practice? Canadian single-centre experience JF - Canadian Journal of Surgery JO - CAN J SURG SP - 44 LP - 51 DO - 10.1503/cjs.012017 VL - 62 IS - 1 AU - Mauro Enrique Tun-Abraham AU - Kerollos N. Wanis AU - Carlos Garcia-Ochoa AU - Nathalie Sela AU - Hemant Sharma AU - Ibrahim Al Hasan AU - Douglas Quan AU - Bandar Al-Judaibi AU - Mark Levstik AU - Roberto Hernandez-Alejandro Y1 - 2019/02/01 UR - http://canjsurg.ca/content/62/1/44.abstract N2 - Background: Outcomes in liver transplantation with organs obtained via donation after cardiocirculatory death (DCD) have been suboptimal compared to donation after brain death, attributed mainly to the high incidence of ischemic cholangiopathy (IC). We evaluated the effect of a 10-year learning curve on IC rates among DCD liver graft recipients at a single centre.Methods: We analyzed all DCD liver transplantation procedures from July 2006 to July 2016. Patients were grouped into early (July 2006 to June 2011) and late (July 2011 to July 2016) eras. Those with less than 6 months of follow-up were excluded. Primary outcomes were IC incidence and IC-free survival rate.Results: Among the 73 DCD liver transplantation procedures performed, 70 recipients fulfilled the selection criteria, 32 in the early era and 38 in the late era. Biliary complications were diagnosed in 19 recipients (27%). Ischemic cholangiopathy was observed in 8 patients (25%) in the early era and 1 patient (3%) in the late era (p = 0.005). The IC-free survival rate was higher in the late era than the early era (98% v. 79%, p = 0.01). The warm ischemia time (27 v. 24 min, p = 0.049) and functional warm ischemia time (21 v. 17 min, p = 0.002) were significantly lower in the late era than the early era.Conclusion: We found a significant reduction in IC rates and improvement in IC-free survival among DCD liver transplantation recipients after a learning curve period that was marked by more judicious donor selection with shorter procurement times. ER -