PT - JOURNAL ARTICLE AU - Darren Costain AU - Graham Elder AU - Brian Fraser AU - Brad Slagel AU - Adrienne Kelly AU - Yifun Cheong AU - Luke Fera TI - Topical tranexamic acid in hip fractures: a randomized, placebo-controlled double-blinded study AID - 10.1503/cjs.014220 DP - 2021 Aug 01 TA - Canadian Journal of Surgery PG - E449--E456 VI - 64 IP - 4 4099 - http://canjsurg.ca/content/64/4/E449.short 4100 - http://canjsurg.ca/content/64/4/E449.full SO - CAN J SURG2021 Aug 01; 64 AB - Background: Tranexamic acid (TXA) has been shown to reduce perioperative blood loss in elective orthopedic surgery. The safety of intravenous TXA in nonelective hip fracture surgery is uncertain. The purpose of this study was to evaluate the efficacy and safety of topical TXA in hip fracture surgery.Methods: Adult patients presenting to a community hospital with a hip fracture requiring surgery were randomly assigned to receive topical TXA or placebo. Hemoglobin and troponin I levels were measured preoperatively and on postoperative days 1, 2 and 3. All postoperative blood transfusions were recorded. Complications, including acute coronary syndrome (ACS), venous thromboembolism (VTE), cerebrovascular accidents (CVA), surgical site infections (SSI) and 90-day mortality, were recorded.Results: Data were analyzed for 65 patients (31 in the TXA group, 34 in the control group). Hemogloblin level was significantly higher on postoperative days 1 and 2 in the TXA group than in the control group. The difference in hemoglobin level between the groups was not statistically significant by postoperative day 3. Significantly fewer units of packed red blood cells were transfused in the TXA group (2 units v. 8 units); however, 2 of the units in the control group were given intraoperatively, and when these were excluded the difference was not significant. The incidence of ACS, CVA, VTE, SSI, transfusion and all-cause mortality at 90 days did not differ significantly between the groups.Conclusion: Topical TXA reduces early postoperative blood loss after hip fracture surgery without increased patient risk.Trial registration: Clinicaltrials.gov, no. NCT02993341.