TY - JOUR T1 - Serrated polyps and polyposis of the colon: a brief review for surgeon endoscopists JF - Canadian Journal of Surgery JO - CAN J SURG SP - E561 LP - E566 DO - 10.1503/cjs.018820 VL - 64 IS - 6 AU - Eric Hyun AU - Ramzi M. Helewa AU - Harminder Singh AU - H. Robert Wightman AU - Jason Park Y1 - 2021/11/02 UR - http://canjsurg.ca/content/64/6/E561.abstract N2 - Serrated polyps (SPs) were once considered benign, clinically unimportant lesions. However, it is now recognized that through the serrated neoplasia pathway (SNP), SPs play a role in the development of 15%–30% of cases of colorectal cancers (CRC). Furthermore, a high proportion of postcolonoscopy CRCs are believed to arise from SNP. Serrated polyps are classified into hyperplastic polyps, sessile serrated lesions, sessile serrated lesions with dysplasia, traditionally serrated adenomas, and unclassified serrated adenoma, each with a distinct morphological and molecular profile. Despite improved understanding, SPs remain a clinical challenge owing to evolving terminology, frequent pathologic misclassification, endoscopic underdetection, and high rates of incomplete removal. Surgeon endoscopists and surgeons who perform colorectal procedures will undoubtedly come across patients with SPs, and this paper summarizes some of the clinical challenges they will encounter. We also discuss the diagnosis and management of patients with serrated polyposis syndrome (SPS). ER -