PT - JOURNAL ARTICLE AU - Christopher Wolff AU - Farid Muakkassa AU - Robert Marley AU - Ayah El-Khatib AU - Courtney Docherty AU - Linda Muakkassa AU - Hannah Stephen AU - Ann Salvator TI - Routine platelet transfusion in patients with traumatic intracranial hemorrhage taking antiplatelet medication: Is it warranted? AID - 10.1503/cjs.018120 DP - 2022 Mar 15 TA - Canadian Journal of Surgery PG - E206--E211 VI - 65 IP - 2 4099 - http://canjsurg.ca/content/65/2/E206.short 4100 - http://canjsurg.ca/content/65/2/E206.full SO - CAN J SURG2022 Mar 15; 65 AB - Background: After a traumatic intracranial hemorrhage (tICH), patients often receive a platelet transfusion to reverse the effects of antiplatelet medication and to reduce neurologic complications. As platelet transfusions have their own risks, this study evaluated their effects on tICH progression, need for operations and mortality.Methods: In this retrospective study, we identified patients admitted to a level 1 trauma centre with a tICH from 2011 to 2015 who were taking acetylsalicylic acid (ASA) or clopidogrel, or both. We categorized patients into 2 groups: platelet transfusion recipients and nonrecipients. We collected data on demographic characteristics, changes in brain computed tomography findings, neurosurgical interventions, in-hospital death and intensive care unit (ICU) length of stay (LOS). We used multivariable logistic regression to compare outcomes between the 2 groups.Results: We identified 224 patients with tICH, 156 (69.6%) in the platelet transfusion group and 68 (30.4%) in the no transfusion group. There were no between-group differences in progression of bleeds or rates of neurosurgical interventions. In the transfusion recipients, there was a trend toward increased ICU LOS (adjusted odds ratio [OR] 1.59, 95% confidence interval [CI] 0.74–3.40) and in-hospital death (adjusted OR 3.23, 95% CI 0.48–21.74).Conclusion: There were no differences in outcomes between patients who received platelet transfusions and those who did not; however, the results suggest a worse clinical course, as indicated by greater ICU LOS and mortality, in the transfusion recipients. Routine platelet transfusion may not be warranted in patients taking ASA or clopidogrel who experience a tICH, as it may increase ICU LOS and mortality risk.