Clinicopathologic Features of Borrmann’s Type IV Gastric Cancer Versus Other Types of Cancer*
| Variable | Type | p value | |||
|---|---|---|---|---|---|
| IV | I | II | III | ||
| Number | 88 | 26 | 86 | 197 | |
| Gender | < 0.01 | ||||
| Male | 44 (50) | 19 (73) | 64 (74) | 136 (69) | |
| Female | 44 (50) | 7 (27) | 22 (26) | 61 (31) | |
| Age, yr | 57.3 | 68.1 | 63.9 | 64.4 | < 0.0005 |
| Tumour size, cm | 10.5 | 4.8 | 4.9 | 6.6 | < 0.0001 |
| Depth of invasion | < 0.001 | ||||
| TI (m, sm) | 1 (1) | 8 (32) | 5 (6) | 3 (2) | |
| TII (mp, ss) | 20 (24) | 15 (60) | 55 (65) | 85 (43) | |
| TIII (se) | 44 (52) | 2 (8) | 21 (25) | 71 (40) | |
| TIV (si) | 19 (23) | 0 | 3 (4) | 29 (15) | |
| Unknown | 4 | 1 | 2 | 9 | |
| Histologic type | < 0.001 | ||||
| Intestinal | 13 (16) | 19 (73) | 47 (56) | 99 (53) | |
| Diffuse | 69 (84) | 7 (27) | 37 (44) | 89 (47) | |
| Unknown | 6 | 0 | 2 | 9 | |
| Cancer–stromal relationship | < 0.001 | ||||
| Scirrhous | 60 (80) | 4 (18) | 14 (18) | 46 (26) | |
| Intermediate | 10 (13) | 6 (27) | 40 (50) | 82 (46) | |
| Medullary | 5 (7) | 12 (55) | 26 (32) | 50 (28) | |
| Unknown | 13 | 4 | 6 | 19 | |
| Histologic growth pattern | < 0.001 | ||||
| Expansive | 2 (3) | 7 (32) | 12 (15) | 16 (9) | |
| Intermediate | 11 (15) | 12 (55) | 49 (62) | 101 (56) | |
| Infiltrative | 58 (82) | 3 (13) | 18 (23) | 62 (35) | |
| Unknown | 17 | 4 | 7 | 18 | |
| Nodal involvement | < 0.001 | ||||
| Positive | 77 (92) | 8 (33) | 55 (65) | 158 (83) | |
| Negative | 7 (8) | 16 (67) | 29 (35) | 32 (17) | |
| Unknown | 4 | 2 | 2 | 7 | |
| Lymphatic invasion | < 0.001 | ||||
| Positive | 68 (87) | 10 (42) | 55 (66) | 145 (79) | |
| Negative | 10 (13) | 14 (58) | 28 (34) | 38 (21) | |
| Unknown | 10 | 2 | 3 | 14 | |
| Vascular invasion | < 0.01 | ||||
| Positive | 27 (35) | 2 (8) | 13 (16) | 55 (30) | |
| Negative | 50 (65) | 22 (92) | 69 (84) | 128 (70) | |
| Unknown | 11 | 2 | 4 | 14 | |
| Operation | |||||
| Total gastrectomy | 48 (55) | 8 (31) | 22 (26) | 78 (40) | |
| Distal gastrectomy | 31 (35) | 16 (62) | 59 (68) | 105 (53) | |
| Gastrojejunostomy | 2 (2) | 0 | 0 | 4 (2) | |
| Exploratory laparotomy | 5 (6) | 0 | 0 | 4 (2) | |
| Others | 2 (2) | 2 (7) | 5 (6) | 6 (3) | |
| Cause of death | |||||
| Peritonitis carcinomatosa | 35 | 0 | 5 | 23 | |
| Liver metastasis | 0 | 2 | 6 | 15 | |
| Other recurrence | 22 | 0 | 5 | 18 | |
| Other disease | 2 | 0 | 1 | 1 | |
↵* Numbers in parentheses are percentages.
m = mucosa, sm = submucosa, mp = muscularis propria, ss = subserosa, se = tumour penetration of serosa, si = tumour invasion of adjacent structures.