Table 1

Concentration of plasma coagulation factors (c_i) in transfusate and hematocrit (h_i) of transfusate^*

PRBC, B unit(s)	FFP, F unit(s)	Colloid/crystalloid that remains intravascularly after redistribution, C mL	c_i %	h_i %	c_i/(1−h₁),%
2	3	100	0.52	0.29	0.73
1	1	100	0.38	0.32	0.56
1	1	200	0.33	0.28	0.46
2	1	100	0.26	0.44	0.47
2	1	200	0.24	0.4	0.40
2	1	300	0.22	0.37	0.35
3	1	0	0.22	0.55	0.48
3	1	100	0.20	0.51	0.40
3	1	200	0.19	0.47	0.36
3	1	300	0.17	0.43	0.30

Note: FFP = fresh frozen plasma; PRBC= packed red blood cells.
↵* Assuming each unit of PRBC has a volume of 300 mL, with a hematocrit of 0.7, and each unit of FFP has a volume of 250 mL with factor concentration of 1 unit/mL, c_i = 250F/(300B + 250F +C), and h_i = 0.7(300B)/(300B + 250F +C). With time, the patient’s hematocrit and plasma factor concentration eventually reach h_i and c_i/(1−h_i), respectively. Without in-vivo factor production, transfusion combinations that could never reach a plasma factor concentration ≥ 50% of normal are italicized. The amounts of colloid or crystalloid (typically normal saline) are chosen for illustrative purpose only. In actual resuscitation, varying amounts of such fluids are typically given. The amount of colloid or crystalloid that remains intravascularly influences both the hematocrit and coagulation concentration as shown in the above equations.