Randomized trials of regional anesthesia (RA) versus general anaesthesia in total joint arthroplasty of the lower limb reporting blood loss or blood transfusion requirements
| Trial | Year | Joint studied | Regional anesthesia arm technique | N | Outcome |
|---|---|---|---|---|---|
| Keith (5) | 1977 | Hip | Epidural | 27 | RA better |
| Hole et al (6) | 1980 | Hip | Epidural | 60 | ND |
| Modig et al (7) | 1980 | Hip | Epidural | 16 | RA better |
| Thorburn et al (8) | 1980 | Hip | Spinal | 85 | RA better |
| Hole et al (9) | 1982 | Hip | Epidural | 18 | ND |
| Chin et al (10) | 1982 | Hip | Epidural | 42 | RA better |
| Bonnet et al (11) | 1982 | Hip | Epidural | 19 | ND |
| Riis et al (12) | 1983 | Hip | Epidural | 30 | ND |
| Modig et al (13) | 1983 | Hip | Epidural | 30 | RA better |
| Hole (14) | 1984 | Hip | Epidural | 20 | ND |
| Hedenstierna and Lofstrom (15) | 1985 | Both | Spinal | 16 | RA better |
| Modig et al (16) | 1986 | Hip | Epidural | 94 | RA better |
| Jakobsen et al (17) | 1986 | Hip | Epidural | 30 | ND |
| Fredin and Rosberg (18) | 1986 | Hip | Epidural | 60 | ND |
| Modig and Karlstrom (19) | 1987 | Hip | Epidural | 38 | RA better |
| Davis et al (20) | 1987 | Hip | Spinal | 101 | RA better |
| Donadoni et al (21) | 1989 | Hip | Epidural | 80 | ND |
| Neilson et al (22) | 1990 | Knee | Spinal | 64 | ND |
| Salo and Nissila (23) | 1990 | Hip | Spinal | 22 | RA worse |
| Jones et al (24) | 1990 | Both | Spinal | 146 | ND |
| Planes et al (25) | 1991 | Hip | Spinal | 188 | ND |
| Jorgensen et al (26) | 1991 | Knee | Epidural | 39 | ND |
| Dauphin et al (27) | 1997 | Hip | Epidural | 37 | RA better |
| Kohro et al (28) | 1998 | Knee | Epidural | 22 | ND |
| Borghi et al (29) | 2002 | Hip | Epidural | 210 | ND |
Better = less bleeding or transfusion; ND = no difference; RA = regional anesthesia; worse = more bleeding or transfusion.