Are the results valid?
Did the analysis provide a full economic comparison of health care strategies? Were relevant viewpoints considered? Were all relevant clinical strategies compared?
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Were the costs and outcomes properly measured and valued?
Was clinical effectiveness established? Were costs measured accurately? Were data on costs and outcomes appropriately integrated? Was appropriate allowance made for uncertainties in the analysis? Are estimates of costs and outcomes related to the baseline risk in the treatment population?
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What are the results?
What were the incremental costs and outcomes of each strategy? Do incremental costs and outcomes differ among subgroups? How much does allowance for uncertainty change the results?
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Will the results help in me caring for my patients?
Are the benefits worth the harms and the costs? Could my patients expect similar health outcomes? Could I expect similar costs?
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