Study characteristics and quality evaluation of each selected study on the use of antibiotic prophylaxis to prevent postoperative complications in patients undergoing tension-free hernioplasty
| Characteristic | Perez et al. (18) | Yerdel et al. (19) | Aufenacker et al. (20) | Celdran et al. (21) | Tzovaras et al. (22) | Jain et al. (23) |
|---|---|---|---|---|---|---|
| Jadad score | 5 | 4 | 5 | 4 | 5 | 4 |
| Randomization | Yes | Yes | Yes | Yes | Yes | Yes |
| Double blind | Yes | Yes | Yes | Yes | Yes | Yes |
| Lost to follow-up, % | 3.6 | NR | 0.4 | NR | 0.5 | NR |
| No. of patients | 360 | 269 | 1008 | 91 | 379 | 120 |
| Mean age, yr | 61 | 56 | 58 | 58 | 63 | 41 |
| Infection, % | 3.1 | 4.8 | 1.7 | 4.4 | 3.7 | 1.7 |
| Wound infection definition | CDC criteria | CDC criteria | CDC criteria | CDC criteria | Clinical criteria | Clinical criteria |
| Follow-up | 1 mo | 1 yr | 3 mo | 2 yr | 1 mo | 1 mo |
| Antibiotic, type and dosage | Cefazolin, 1 g | Ampicillin + sulbactam, 1.5 g | Cefuroxime, 1.5 g | Cefazolin, 1 g | Ampicillin + clavulanic acid, 1.2 g | Amoxicillin + clavulanic acid, 1.2 g |
| Control | Placebo* | Placebo* | Placebo* | NR | Placebo* | Placebo* |
| Duration of surgery, min | 53 | 63 | 40 | 65 | 45 | 58 |
| Mesh type | Polypropylene | Polypropylene | Polypropylene | Polypropylene | Polypropylene | Polypropylene |
CDC = Centers for Disease Control and Prevention; NR = not reported.
↵* Placebo = saline solution.