Univariable and multivariable analysis of overall survival using Cox proportional hazards model
| Variable | Reference | Univariate | Multivariate | ||
|---|---|---|---|---|---|
| HR (95%CI) | p value | HR (95%CI) | p value | ||
| Treatment: NAC | PCS | 2.56 (1.91–3.42) | < 0.001 | 2.31 (1.70–3.13) | < 0.001 |
| Age at diagnosis > 50 yr | ≤ 50 yr | 1.52 (1.09–2.11) | 0.014 | — | — |
| Suboptimal debulking status | Optimal | 1.77 (1.30–2.40) | < 0.001 | 1.58 (1.15–2.17) | 0.005 |
| Resistant to platinum-based chemotherapy | Sensitive | — | < 0.001* | — | — |
| Cycles of primary chemotherapy > 6 | ≤ 6 | 1.92 (1.43–2.56) | < 0.001 | — | — |
CI = confidence interval, HR = hazard ratio; NAC = neoadjuvant chemotherapy and interval cytoreductive surgery; PCS = primary cytoreductive surgery and adjuvant chemotherapy.
↵* Log-rank test. Sensitivity to platinum-based chemotherapy has nonproportional hazard. It was included in the multivariate analysis as a stratification factor.