Association between the age of transfused blood and trauma patient outcomes
| Study | Age of blood transfused* (quantity) | Outcome | OR (95% CI) | RR (95% CI) |
|---|---|---|---|---|
| Hassan et al. (31) | Old (≥ 7u) | Mortality | NS | — |
| Old (≥ 7u) | Complicated sepsis | 1.9 (1.1–3.4) | — | |
| Murrell et al. (36) | Old | In-hospital mortality | NS | — |
| Old | Need for ICU care | NS | — | |
| Old | Longer ICU stay | — | 1.15 (1.11 – 1.20) | |
| Phelan et al. (35) | Mean 14 d | Mortality | 0.426 (0.182 – 0.998) | — |
| Mean 21 d | Mortality | 0.439 (0.225 – 0.857) | — | |
| Spinella et al. (32) | Old (≥ 5u) | In-hospital mortality | 4.0 (1.34 – 11.61) | — |
| Old (≥ 10u) | In-hospital mortality | 8.9 (2 – 40) | — | |
| Weinberg et al. (33) | Old (overall) | Mortality | NS | — |
| Old (1–2u) | Mortality | NS | — | |
| Old (≥ 3u) | Mortality | 2.18 (1.00 – 4.97) | — | |
| Weinberg et al. (30) | New | Mortality | NS | — |
| Old | Mortality | 1.12 (1.02 – 1.23) | — | |
| New | Renal dysfunction | NS | — | |
| Old | Renal dysfunction | 1.18 (1.07 – 1.29) | — | |
| New | Pneumonia | NS | — | |
| Old | Pneumonia | 1.10 (1.04 – 1.17) | — | |
| New | ARDS | NS | — | |
| Old | ARDS | NS | — | |
| Weinberg et al. (34) | 1–2u old v. new | In-hospital mortality | — | NS |
| ≥ 3u old v. new | In-hospital mortality | — | 1.57 (1.14 – 2.15) |
ARDS = acute respiratory distress syndrome; CI = confidence interval; ICU = intensive care unit; OR = odds ratio; NS = not significant; RR = relative ristk; u = unit(s).
↵* Based on individual study definitions for old and new blood.