Study and patient characteristics
| Characteristic | Study | ||||||
|---|---|---|---|---|---|---|---|
| Hassan et al. (31) | Murrell et al. (36) | Phelan et al. (35) | Spinella et al. (32) | Weinberg et al. (33) | Weinberg et al. (30) | Weinberg et al. (34) | |
| No. of patients | 820 | 275 | 399 | 202 | 1813 | 1624 | 1647 |
| Study type | R, C, SC | R, C, SC | R, C, SC | R, C, SC | R, C, SC | R, C, SC | R, C, SC |
| Age, yr, mean or median [IQR] | 40 | 37 [22–53] | 41.6 | 46.5 | 41 | 43.2 | 41.3 |
| Male sex, % | 67 | 67 | 78.2 | 74.8 | 65 | 70.6 | 66.7 |
| Blunt mechanism, % | 89 | NR | 76.4 | 92.6 | 76 | 100 | 74.4 |
| ISS, mean (range) or median [IQR] | 27 [18–34] | 18 [10–29] | 29 [22.0–39.5] | 24 (13.5–34) | 26 (NR) | 14.4 (1–24) | 26.3 (NR) |
| Overall mortality, % | 14 | 19 | 19.5 | 20.3 | 10 | 17.7 | 2.7 |
| Inclusion criteria | Transfusion in ICU within 24 hr | Transfusion of ≥ 1u pRBC | Transfusion ≥ 6u pRBC, surviving 48 hr | Transfusion ≥ 5u pRBC, ICU admission | Transfusion ≥ 1u pRBC in 24 hr | ISS < 25, no pRBC given in first 48 hr, ICU admission | Transfusion ≥ 1u pRBC in 24 hr |
| Exclusion criteria | NR | NR | NR | Patients who died in the ED | Patients who died within the first 24–48 hr | Patients who died within first 24–48 hr | Patients given new and old blood in first 24 hr |
| New blood definition, d in storage | ≤ 14 | Variable | Mean 14 | < 28 | < 14 | < 14 | < 14 |
| Old blood definition, d in storage | > 14 | Variable | Mean 21 | ≥ 28 | ≥ 14 | ≥ 14 | ≥ 14 |
| Total pRBC units transfused, mean ± SD, mean (range) or median [IQR] | 6 [4–11] | 3 [2–6] | 16.5 ± 16.3 | 9 [6–12.5] | 4.9 (NR) | 5.2 (1–104) | 3.2 ± 1.8 |
C = cohort; ED = emergency department; ICU = intensive care unit; ISS = injury severity score; IQR = interquartile range; NR = not reported; pRBC = packed red blood cells; R = retrospective; SC = single centre; SD = standard deviation; u = unit(s).