Multivariate analysis of potential risk factors for progression (generalized estimating equation analysis)
| Variable | OR (95% CI) | |
|---|---|---|
| Progression to any dysplasia | Progression to high-grade dysphasia/EAC | |
| Age, yr | ||
| < 60 | 1.0 | 1.0 |
| ≥ 60 | 3.5 (1.7–7.4) | 5.1 (1.6–16.6) |
| Sex | ||
| Female | 1.0 | 1.0 |
| Male | 2.1 (0.8–5.6) | 2.6 (0.6–11.1) |
| Hiatal hernia | ||
| No | 1.0 | 1.0 |
| Yes | 0.8 (0.5–1.3) | 0.9 (0.5–1.3) |
| Esophagitis | ||
| No | 1.0 | 1.0 |
| Yes | 0.6 (0.3–1.4) | 1.2 (0.4–3.2) |
| Ulcer | ||
| No | 1.0 | 1.0 |
| Yes | 1.9 (0.9–4.5) | 0.9 (0.2–1.17) |
| Mucosal irregularities | ||
| No | 1.0 | 1.0 |
| Yes | 3.3 (0.8–13.8) | 8.6 (2.4–30.4) |
| Length of Barrett’s esophagus segment, cm | ||
| < 3 | 1.0 | 1.0 |
| ≥ 3 | 1.2 (1.1–1.3) | 1.1 (0.9–1.17) |
CI = confidence interval; EAC = esophageal adenocarcinoma; OR = odds ratio.