Study and country | No. of patients | Study design | Sex | Age, yr | Location of surgery (%) | Type(s) of procedure(s) | Recurrence rate, % |
---|---|---|---|---|---|---|---|
Walter et al. (22) 2018 Germany | 48 | Single centre, retrospective | WLE | 54.2 | |||
Deckers et al. (13) 2018 The Netherlands | 84 | Single centre, retrospective | 48 men (57.1%), 36 women (42.9%) | Axillary (22.1), inguinal/ femoral (37.2), genital (12.3), gluteal/anal (25), other (2.8) | WLE with secondary intention closure | 38 | |
Kofler et al. (25) 2018 Germany | 255 | Retrospective, questionnaires | 103 men, 152 women, | Median 38 (range 14–66) | Inguinal (62), axillary (54), genital (50), gluteal (41), coccygeal (24), pectoral (17) | WLE with secondary intention closure | 69* |
Humphries et al. (26) 2016 United States | 17 | Single centre, retrospective | 4 men, 13 women | Mean for all procedures 36.8 (range 18–65) | Axillary, breast, inguinal area, perineum, mons pubis/suprapubis, presacrum, perianus, abdomen, inner thighs, gluteal | WLE with secondary intention closure (including multiple excisions) | 11.8 |
Blok et al. (21) 2015 The Netherlands | 113 | Retrospective | 36 men (31.9%), 77 women (68.1%) | NA | Axilla, inguinal, genital, gluteal, other | Local excision and deroofing | 29.2 |
Wormald et al. (27) 2014 United Kingdom | 27 | Retrospective, questionnaires | 8 men (30%), 19 women (70%) | Mean 34.7 | Axilla | WLE Graft, flaps | 3.7 |
van Rappard et al. (28) 2012 The Netherlands | 57 | Retrospective, questionnaires | 10 men (18%), 47 women (82%) | Average 42.5 | Axilla, inguinal, genital, perianal | Local excision and primary closure | 34 |
Alharbi et al. (29) 2012 Germany | 32 | Retrospective | 12 men (37.5%), 20 women (62.5%) | Range 17–51 | Axilla, inguinal, perianal/ perineal, gluteal, inframammary | WLE Primary closure flap, graft | 16.75 |
Büyükasik et al. (30) 2011 Turkey | 15 | Retrospective | Mean (SD 10.6) | Groin, axilla, buttocks, nuchae, perianal, perineal | WLE Primary closure, with fasciocutaneous flaps and with split-thickness skin grafts | 5.5 | |
van der Zee et al. (23) 2010 The Netherlands | 44 | 88 deroofed lesions | 41 women, 3 men | Median 35 (range 28–43) | Axillae (44.3), groin (46.6), buttocks (9.1) | Deroofing technique | 17 |
Civelek et al. (31) 2010 Turkey | 14 | Retrospective | 9 women, 5 men | Not provided | Axilla, inguinal | WLE Flap, graft | 29 |
Menderes et al. (32) 2010 Turkey | 27 | 54 sites | 19 men, (70%) 8 women (30%), | 41.2 (range 24–58) | Axilla (42), gluteal (20), perineal (24), inguinal (12) | Primary closure flap, graft | 7.5 |
Rieger et al. (33) 2009 Switzerland and Austria | 8 | Retrospective | 7 women (87.5%) 1 man (12.5%) | Mean 35 (range 18–49) | Inguinal | WLE, flap | 0 |
Mandal et al. (34) 2005 Scotland | 106 | Median at onset 36 (range 17–70) | Both axillae (36.2), 1 axilla (21.6), axilla and groin (9.0), groin only (14.6), perineum (9.0), inframammary (5.5), other (3.4) | Primary closure (100 sites), split skin graft (29 sites), flaps (14 sites) | 70† | ||
Kagan et al. (35) 2005 United States | 57 | 15 men (26%), 42 women (74%) | Mean 34 (range 19–62) | Axilla (50), perineum (36), inguinal (14) | Local, wide, other Primary, graft, secondary wound healing Excision and primary closure for localized disease (76% of axillary cases WLE with or without STSG with diffuse disease (86% of inguinoperineal cases) | Not provided | |
Altmann et al. (36) 2004 Germany | 20 | Retrospective | 6 men (30%), 14 women (70%) | Average 36 (range 20–50) | Axilla | WLE and flaps | 15 |
Kuo and Ohara (37) 2003 Japan | 6 | Retrospective | 4 men (66%), 2 women (33%) | Average 32.7 | Gluteal | WLE and grafts | 0 |
Bocchini et al. (38) 2003 Brazil | 56 | Retrospective | 52 men (93%), 36 women (64%) | Mean 40 | Gluteal, perineal, inguinal | WLE Secondary intention healing, delayed skin grafting‡ | 1.8 |
Tanaka et al. (39) 2001 Japan | 19 | Retrospective | Mean 40.7 (range 30–58) | Axillary, inguinal, gluteal areas, other | WLE Primary flaps, graft | 43 | |
Bohn and Svensson (40) 2001 Sweden | 138 | Retrospective, questionnaires | Average 23 | Axilla, inguinal, perineal/ perianal, inframammary, other | WLE Primary graft | 33 | |
Soldin et al. (19) 2000 South Africa | 59 | 42 women, 17 men | Average 32 (range 16–65) | Axilla | Local excision and WLE Primary closure, flap, graft | 26.6§, 7.7¶ | |
Rompel et al. (41) 2000 Germany | 106 | Inguinal (70.8), axillary (61.3) | WLE | 2.5 |
PMH = past medical history; SD = standard deviation; STSG = split-thickness skin grafting; WLE= wide local excision.
↵* Reported by patients via questionnaires.
↵† In the primary closure series.
↵‡ Secondary intention healing in 32 patients (57.1%); delayed skin grafting in 24 patients (42.9%).
↵§ Local excision.
↵¶ Excision of all hair-bearing skin.