Odds ratio of risk for nonadherence to adjuvant breast cancer therapy
| Factor | 100% adherence, OR (95% CI) | 80% adherence, OR (95% CI) | ||
|---|---|---|---|---|
| Univariate | Multivariate | Univariate | Multivariate | |
| Age, yr | ||||
| 29–49 | — | 0.572 (0.188–1.736) | — | 1.432 (0.218–9.427) |
| 50–69 | 0.533 (0.233–1.219) | — | 1.103 (0.272–4.472) | — |
| ≥ 70 | 0.159 (0.019–1.321) | — | 0.896 (0.087–9.252) | — |
| Menopause | 0.551 (0.245–1.237) | 2.882 (0.576–14.409)† | 1.217 (0.309–4.784) | 8.377 (0.745–94.218)† |
| Neoadjuvant therapy | 0.458 (0.100–2.098) | 0.468 (0.080–2.731) | 0.733 (0.089–6.072) | 1.993 (0.115–34.695) |
| Postoperative chemotherapy | 2.085 (0.944–4.606) | 1.352 (0.385–4.746) | 3.203 (0.897–11.442) | 31.970 (1.514–674)*† |
| Tamoxifen | 1.640 (0.716–3.756) | 2.390 (0.609–9.375) | 3.441 (0.719–16.472) | 3.210 (0.407–25.29) |
| Aromatase inhibitor | 2.074 (0.832–5.171) | 3.935 (0.879–17.613)† | 0.929 (0.260–3.319) | 0.582 (0.066–5.130) |
| Tumour status | ||||
| T0 | — | 0.657 (0.285–1.515) | — | 0.388 (0.054–2.813) |
| T1 | 1.383 (0.368–5.193) | — | 1.532 (0.180–13.009) | — |
| T2 | 1.026 (0.215–4.886) | — | 0.600 (0.035–10.195) | — |
| T3 | 1.333 (0.108–16.480) | — | 4.500 (0.229–88.243) | — |
| T4 | 1.778 (–0.135–23.399) | — | — | — |
| Node status | ||||
| N0 | — | 1.997 (0.894–4.460)† | — | 1.084 (0.256–4.581) |
| N1 | 1.474 (0.590–3.681) | — | 0.312 (0.037–2.618) | — |
| N2 | 3.583 (1.032–12.441)* | — | 2.442 (0.450–13.246) | — |
| N3 | — | — | — | — |
| HER2-neu positive | 3.536 (1.332–9.387)* | 3.006 (0.913–9.901)† | 12.359 (3.251–46.983)* | 9.190 (1.608–52.52)*† |
| Total mastectomy | 1.288 (0.498–3.336) | 1.670 (0.415–6.718) | 0.927 (0.190–4.523) | 0.434 (0.031–6.104) |
| Axillary dissection | 0.919 (0.418–2.021) | 0.463 (0.124–1.726) | 0.918 (0.268–3.139) | 0.148 (0.011–2.056)† |
| Hormone replacement therapy | 0.271 (0.098–0.750)* | 0.223 (0.060–0.827)*† | 0.363 (0.076–1.738) | 0.093 (0.008–1.113)† |
| Patient’s history of cancer | 0.448 (0.055–3.675) | 0.001 (0–1000) | 1.567 (0.180–13.629) | 0.001 (0–1000) |
| Family history of cancer | 0.571 (0.123–2.656) | 0.971 (0.170–5.564) | 0.838 (0.101–6.977) | 0.001 (0–1000) |
| Family history of breast cancer | 0.561 (0.224–1.409) | 0.600 (0.190–1.897) | 0.773 (0.196–3.042) | 0.582 (0.057–4.999) |
| Other chronic medication | 0.121 (0.016–0.930)* | 0.284 (0.033–2.433) | 0.417 (0.051–3.391) | 0.001 (0–100) |