Review of studies assessing sentinel lymph node biopsy at the time of prophylactic mastectomy
| Study | No. of patients | PM | Bilateral PM | Technique of SLNB | Mastectomy specimen | ||||
|---|---|---|---|---|---|---|---|---|---|
| Invasive cancer | Invasive cancer with SLN+ | Invasive cancer with SLN− | DCIS | SLN+ with no cancer | |||||
| Schrenk et al. (19) | 169 | 169 | 0 | Dye, dye + isotope | 5 | 0 | 5 | 4 | 1 |
| Soran et al. (20) | 80 | 80 | 0 | Dye, dye + isotope | 1 | 0 | 1 | 3 | 2 |
| Boughey et al. (21) | 108 | 108 | 0 | Isotope, dye + isotope | 1 | 0 | 1 | NR* | 2 |
| Black et al. (22) | 52 | 56 | 4 | Dye, isotope, dye + isotope | 1 | 0 | 1 | 5† | 1 |
| McLaughlin et al. (17) | 393 | 453 | 60 | Dye + isotope | 7 | 3 | 4 | 17 | 5 |
| Laronga et al. (23) | 449 | 477 | 28 | Dye, dye + isotope | 6 | 1 | 5 | 12 | 7 |
| Total | 1251 | 1343 | 92 | 21 | 4 | 17 | — | 18 | |
DCIS = ductal carcinoma in situ; NR = not reported; PM = prophylactic mastectomy; SLN = sentinel lymph node; SLNB = sentinel lymph node biopsy.
↵* All patients with DCIS identified at the time of prophylactic mastectomy had negative SLNs, but the number of patients was not reported.
↵† The SLN was positive in 1 of 5 cases.