Multivariable clustered analysis of risk of local recurrence*
| Group | HR (95% CI) | p value | |
|---|---|---|---|
| Arm of trial | |||
| Control group | 1.00 | Reference group | Reference group |
| Experimental group | 0.99 | (0.61–1.61) | 0.98 |
| Radiation group | |||
| No RT | 1.00 | Reference group | Reference group |
| Preoperative RT | 0.92 | (0.37–2.33) | 0.88 |
| Postoperative RT | 1.64 | (1.04–2.58) | 0.027 |
CI = confidence interval; HR = hazard ratio; RT = radiation therapy.
↵* Adjusted for data at hospital level. Controlling for age; sex; comorbidities; stage; distance of tumour from anal verge; tumour size; histologic grade; any vascular, lymphatic, neural invasion; and positive circumferential radial margin.