Factors influencing antibiotic prophylaxis for surgical site infection prevention
| Study | Surgery | Design | Findings |
|---|---|---|---|
| Hawn et al. (44) | Clean and clean-contaminated surgery | Retrospective cohort of 8137 patients at 108 VA hospitals: factors associated with timely antibiotic prophylaxis administration | Early dosing accounted for 79% of untimely prophylaxis. Antibiotic administration in the operating room influenced timely prophylaxis (OR 7.74, 95% CI 6.49–9.22) |
| Turnbull et al. (45) | Clean and clean-contaminated surgery | Prospective cohort of 4441 patients in single tertiary care hospital to assess health system factors influencing appropriate administration of antibiotic prophylaxis | Appropriateness of first dosing improved with written orders (OR 19.7, 95% CI 9.1–42.7, p < 0.001) and orders given in the operating room (OR 13.9, 95% CI 7.5–25.6, p < 0.001); it was reduced with same-day surgery (OR 0.57, 95% CI 0.4–0.82, p < 0.001) |
| Zoutman et al. (40) | Clean surgery (hip-fracture surgery) | Retrospective cohort of 352 patients having surgery at 22 hospitals across Canada in 1990 to assess surgical and organizational factors influencing timing of antibiotic prophylaxis | Lack of a written order, being a nonteaching hospital and shorter duration of surgical procedure were predictive of inappropriate antibiotic prophylaxis |
CI = confidence interval; OR = odds ratio; VA = Veterans Administration.