Major Components of the Edmonton Protocol for Allogeneic Islet Cell Transplantation
| Component | Requirements |
|---|---|
| Sufficient number of high-quality pancreatic islets | Refined pancreas procurement techniques Improved enzyme digestion and purification process Multiple donors as needed for adequate islet-cell mass |
| Recipient selection | “Brittle” type 1 diabetic patients Normal renal function, no severe cardiovascular disease No insulin resistance, moderate insulin requirements |
| Tailored immunosuppression | Sirolimus-based Steroid-free Induction with anti-interleukin-2-receptor antibody Low-dose calcineurin inhibitor |