Contraindications to Streptokinase Administration (The Wellesley Hospital Protocol, Department of Pharmacy, 1994)
| Absolute |
| Active internal bleeding |
| History of stroke within 2 mo |
| Bleeding diathesis |
| Surgical procedure within 10 d |
| Intracranial neoplasm, arteriovenous malformation or aneurysm |
| Severe uncontrolled hypertension (> 200 mm Hg systolic or > 110 mm Hg diastolic) |
| Recent traumatic cardiopulmonary resuscitation |
| Relative |
| Significant gastrointestinal bleeding or active peptic ulcer within 10 d |
| Evidence of transient ischemic attacks |
| High likelihood of left heart thrombus |
| Genitourinary bleeding within 10 d |
| Acute pericarditis |
| Subacute bacterial endocarditis |
| Hemostatic defects including those secondary to severe hepatic or renal disease |
| Significant liver dysfunction |
| Pregnancy or less than 28 days post-partum |
| Diabetic hemorrhagic retinopathy or other hemorrhagic ophthalmic conditions |
| Septic thrombophlebitis or occluded arteriovenous cannula at seriously infected site |
| Streptokinase therapy in the previous 6 mo |
| Confirmed streptococcal infection |