Hemoglobin and international normalized ratio values, and receipt of red blood cell transfusion
| Variable | Group; median (IQR)* | p value* | ||
|---|---|---|---|---|
| PCC | Vitamin K | Control | ||
| Hemoglobin concentration, g/dL− (1) | ||||
| Admission† | 12.1 (11.1–13.7) | 12.7 (11.4–13.8) | 12.5 (11.4–13.4) | 0.6 |
| Postoperative day 1 | 10.0 (8.8–12.2) | 10.5 (9.4–11.8) | 10.6 (9.1–11.6) | 0.8 |
| δ Hemoglobin concentration, mean ± SD‡ | −1.6 ± 1.0 | −2.1 ± 1.4 | −1.7 ± 1.6 | 0.2 |
| International normalized ratio | ||||
| Admission§ | 2.5 (2.3–3.2) | 2.5 (2.1–2.9) | — | 0.3 |
| Postoperative day 1 | 1.8 (1.5–2.1) | 1.2 (1.1–1.4) | — | < 0.05 |
| Postoperative day 3 | 1.7 (1.4–2.4) | 1.2 (1.1–1.5) | — | < 0.05 |
| Postoperative day 5 | 2.4 (1.3–3.2) | 1.9 (1.5–2.3) | — | 0.2 |
| Red blood cell administration, no. (%) of patients | 4 (15) | 21 (32) | 18 (36) | 0.2 |
| Units of red blood cells administered | 1.5 (1.0–2.8) | 2.0 (1.0–2.0) | 2.0 (1.0–2.0) | 0.9 |
IQR = interquartile range; PCC = prothrombin complex concentrate; SD = standard deviation.
↵* For between-group differences determined with the χ2 test with post hoc test or, for quantitative parameters, the Mann–Whitney U test or Kruskal–Wallis test with post hoc analysis with the Dunn test and Bonferroni correction.
↵† Missing for 1 patient in the PCC group and 1 patient in the vitamin K group.
↵‡ Decrease between admission and postoperative day 1.
↵§ Missing for 1 patient in the PCC group.