Univariate and multivariate analyses for hospital mortality in patients supported with VA-ECMO
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | p value | OR | 95% CI | p value | |
| Pretransplant characteristics | ||||||
| Emergent heart transplantation* | 3.34 | 1.04–10.69 | 0.04 | |||
| In ICU at the time of transplantation | 2.99 | 0.85–10.49 | 0.08 | |||
| Waiting time, d | 0.99 | 0.99–1.00 | 0.07 | |||
| Acute liver failure (bilirubin > 30 μmol/L) | 9.64 | 1.15–80.53 | 0.03 | |||
| Low cardiac output syndrome | 2.97 | 0.96–9.06 | 0.05 | |||
| Mean pulmonary arterial pressure, mm Hg | 0.93 | 0.88–0.98 | 0.01 | |||
| MELD-XI score | 1.16 | 1.02–1.31 | 0.02 | |||
| Posttransplant characteristics | ||||||
| Cardiac arrest | 8.25 | 2.39–28.48 | 0.001 | |||
| Maximum adrenaline dose, μg/kg per min | 1.74 | 0.96–2.87 | 0.12 | |||
| Inotrope duration | 0.91 | 0.82–1.00 | 0.06 | |||
| Delayed initiation of VA-ECMO | 8.25 | 2.39–28.48 | 0.001 | 5.11 | 1.08–24.22 | 0.04 |
| Central | 19.6 | 2.41–159.9 | 0.005 | |||
| 24-h bleeding | 1.01 | 1.00–1.02 | 0.05 | 1.00 | 1.00–1.01 | 0.05 |
Note: Univariate testing was used as a prescreening method for inclusion of variables in the multivariable model. The highest threshold used was p < 0.25. CI = confidence interval; ICU = intensive care unit; MELD-XI = Model for End-stage Liver Disease score excluding INR; OR = odds ratio; VA-ECMO = venoarterial extracorporeal membrane oxygenation.
↵* Patients eligible for emergent transplantation included those who were listed as status 4, 4S, 3.5 and 3 in Canada and superurgent or status 1 in France.