Table 3

Multivariable Cox proportional hazard analysis of predictive factors in patients with stage T3 disease stratified by lymph node status

Variable	Lymph node status; HR (95% CI)
Variable	Negative n = 27^*	Positive n = 46^†	Unknown 60 > n < 66^‡
Surgery
Simple	Ref	Ref	Ref
Extended	0.20 (0.03–1.06)	0.63 (0.30–1.34)	2.06 (0.78–5.49)
Sex
Male	Ref	Ref	Ref
Female	1.09 (0.32–3.70)	0.47 (0.21–1.04)	0.71 (0.37–1.34)
Age	0.99 (0.92–1.07)	1.00 (0.97–1.04)	1.05 (1.02–1.08)
Grade
Well	Ref	Ref	Ref
Moderate	0.96 (0.16–5.72)	0.97 (0.34–2.79)	1.07 (0.45–2.55)
Poor	2.10 (0.31–14.5)	2.22 (0.83–5.94)	1.15 (0.48–2.75)
Perineural invasion
Absent	Ref	Ref	Ref
Present	0.51 (0.08–3.58)	1.66 (0.57–4.84)	0.93 (0.37–2.30)
Unknown	0.64 (0.10–4.00)	0.90 (0.24–3.34)	1.52 (0.59–3.93)
Lymphovascular invasion
Absent	Ref	Ref	Ref
Present	1.71 (0.38–7.77)	0.52 (0.14–2.02)	1.78 (0.84–3.79)
Unknown	0.13 (0.01–1.47)	0.39 (0.08–1.79)	0.69 (0.27–1.78)

CI = confidence interval; HR = hazard ratio; Ref = reference.
↵* 4 simple, 23 extended.
↵† 23 simple, 23 extended.
↵‡ 60 simple, < 6 extended (cells with fewer than 6 cases are suppressed to protect confidentiality).