Characteristic | No. (%) of patients; MELD score* | p value | ||
---|---|---|---|---|
Total n = 332* | MELD ≤ 35 n = 280 | MELD > 35 n = 52 | ||
MELD score | < 0.001 | |||
≤ 35 | 280 (84.3) | 280 (100) | 0 (0.0 ) | |
> 35 | 52 (15.7 ) | 0 (0.0 ) | 52 (100 ) | |
Recipient age, yr, median (IQR) | 57.0 (49.0–62.0) | 57.0 (50.0–62.0) | 55.5 (44.0–59.2) | 0.044 |
Recipient sex, n = 331 | 0.72 | |||
Female | 125 (37.8 ) | 107 (38.4 ) | 18 (34.6 ) | |
Male | 206 (62.2 ) | 172 (61.6 ) | 34 (65.4 ) | |
Donor age, yr, median (IQR) | 45.5 (30.0–56.0) | 45.0 (30.0–56.0) | 47.0 (27.0–57.2) | 0.78 |
Recipient D-MELD score, median (IQR) | 846 (495–1211) | 728 (446–1067) | 1788 (1063–2259) | < 0.001 |
Donor type, n = 329 | 1.00 | |||
DCD | 53 (16.1 ) | 45 (16.2 ) | 8 (15.7 ) | |
NDD | 276 (83.9 ) | 233 (83.8 ) | 43 (84.3 ) | |
Wait-list status, n = 330 | < 0.001 | |||
1 | 190 (57.6 ) | 189 (68.0 ) | 1 (1.9 ) | |
2 | 89 (27.0 ) | 64 (23.0 ) | 25 (48.1 ) | |
3 | 13 (3.9 ) | 5 (1.8) | 8 (15.4 ) | |
4 | 38 (11.5 ) | 20 (7.2 ) | 18 (34.6 ) | |
Child–Pugh score, median (IQR), n = 324 | 10.0 (8.00–12.0) | 10.0 (8.00–11.0) | 12.0 (11.0–12.2) | < 0.001 |
Recipient hepatitis C status, n = 330 | 0.16 | |||
Negative | 233 (70.6) | 193 (68.9 ) | 40 (80.0 ) | |
Positive | 97 (29.4 ) | 87 (31.1 ) | 10 (20.0 ) | |
ASA class, n = 327 | 0.005 | |||
2 | 1 (0.3) | 1 (0.4 ) | 0 (0.0 ) | |
3 | 51 (15.6 ) | 49 (17.8) | 2 (3.9) | |
4 | 269 (82.3 ) | 223 (80.8 ) | 46 (90.2 ) | |
5 | 6 (1.8 ) | 3 (1.1 ) | 3 (5.9) | |
Dialysis before OLTx, n = 330 | < 0.001 | |||
No | 282 (85.5 ) | 261 (93.9 ) | 21 (40.4 ) | |
Yes, newly started because of AKI | 41 (12.4 ) | 12 (4.3) | 29 (55.8 ) | |
Yes, on previously because of CKD | 7 (2.1) | 5 (1.8) | 2 (3.8 ) | |
Prior 3-mo GFR, mL/min per 1.73 m2, median (IQR), n = 279 | 86.0 (62.5–104) | 85.5 (60.2–104) | 90.0 (72.0–105) | 0.51 |
Prior portal vein thrombosis | 0.027 | |||
No | 266 (80.1 ) | 218 (77.9 ) | 48 (92.3 ) | |
Yes | 66 (19.9 ) | 62 (22.1 ) | 4 (7.7) | |
Prior portal hypertension | 1.00 | |||
No | 84 (25.3 ) | 71 (25.4 ) | 13 (25.0 ) | |
Yes | 248 (74.7 ) | 209 (74.6 ) | 39 (75.0 ) | |
Prior laparotomy | 0.016 | |||
No | 229 (69.0 ) | 201 (71.8 ) | 28 (53.8 ) | |
Yes | 103 (31.0 ) | 79 (28.2) | 24 (46.2 ) | |
Prior OLTx | 0.002 | |||
No | 294 (88.6 ) | 255 (91.1) | 39 (75.0 ) | |
Yes | 38 (11.4 ) | 25 (8.9 ) | 13 (25.0 ) |
AKI = acute kidney injury; ASA = American Society of Anesthesiologists; CKD = chronic kidney dysfunction; DCD = circulatory determination of death; D-MELD = recipient MELD score × donor age; GFR = glomerular filtration rate; IQR = interquartile range; MELD = Model for End-Stage Liver Disease; NDD = neurologic determination of death; OLTx = orthotopic liver transplantation.
↵* Unless indicated otherwise.