Univariable analysis predicting patient death
| Variable | No. (%) of patients* | Hazard ratio (95% CI) | p value | |
|---|---|---|---|---|
| Survived n = 239 | Deceased n = 62 | |||
| MELD score | ||||
| ≤ 35 | 209 (87.4 ) | 52 (83.9 ) | ||
| > 35 | 30 (12.6 ) | 10 (16.1 ) | 1.36 (0.69–2.68) | 0.37 |
| Recipient age, yr, mean ± SD | 53.5 ± 12.0 | 57.2 ± 10.9 | 1.03 (1.00–1.06) | 0.022 |
| D-MELD score, mean ± SD | 873 ± 505 | 996 ± 672 | 1.00 (1.00–1.00) | 0.11 |
| Donor type | ||||
| DCD | 38 (16.0 ) | 9 (14.5 ) | Ref. | Ref. |
| NDD | 199 (84.0 ) | 53 (85.5 ) | 1.08 (0.53–2.19) | 0.83 |
| Wait-list status | ||||
| 1 | 144 (60.5 ) | 30 (48.4) | Ref. | Ref. |
| 2 | 68 (28.6 ) | 13 (21.0 ) | 0.88 (0.46–1.68) | 0.69 |
| 3 | 6 (2.52 ) | 4 (6.45 ) | 3.44 (1.21–9.76) | 0.021 |
| 4 | 20 (8.40) | 15 (24.2 ) | 2.93 (1.58–5.46) | 0.001 |
| Dialysis before OLTx | ||||
| No | 214 (89.9) | 47 (77.0 ) | Ref. | Ref. |
| Yes, because of AKI | 19 (7.98 ) | 13 (21.3) | 3.08 (1.66–5.70) | < 0.001 |
| Yes, because of CKD | 5 (2.10 ) | 1 (1.64 ) | 0.88 (0.12–6.36) | 0.90 |
| Prior 3-mo GFR, mL/min per 1.73 m2, mean ± SD | 82.1 ± 28.7 | 82.3 ± 28.5 | 1.00 (0.99–1.01) | 0.96 |
| Recipient HCV status | ||||
| Negative | 164 (68.9 ) | 43 (70.5 ) | Ref. | Ref. |
| Positive | 74 (31.1 ) | 18 (29.5 ) | 0.90 (0.52–1.56) | 0.71 |
| History of PVT | ||||
| No | 192 (80.3 ) | 49 (79.0 ) | Ref. | Ref. |
| Yes | 47 (19.7 ) | 13 (21.0 ) | 1.05 (0.57–1.93) | 0.88 |
| Prior OLTx | ||||
| No | 219 (91.6) | 49 (79.0 ) | Ref. | Ref. |
| Yes | 20 (8.37 ) | 13 (21.0 ) | 2.69 (1.46–4.96) | 0.002 |
AKI = acute kidney injury; CI = confidence interval; CKD = chronic kidney dysfunction; DCD = circulatory determination of death; D-MELD = recipient MELD score × donor age; GFR = glomerular filtration rate; HCV = hepatitis C virus; MELD = Model for End-Stage Liver Disease; NDD = neurologic determination of death; OLTx = orthotopic liver transplant; PVT = portal vein thrombosis; Ref. = reference category; SD = standard deviation.
↵* Unless indicated otherwise.