Comparisons of kidney donor characteristics based on premortem anticoagulation practices
| Variable | Heparin use n = 173 | Heparin timing* n = 152 | Heparin dose† n = 156 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Yes n = 160 | No n = 13 | p value | Early n = 70 | Delay n = 82 | p value | High n = 11 | Low n = 45 | p value | |
| Age, median (IQR) | 48 (32–56) | 49 (47–52) | 0.62 | 47 (34–57) | 47 (32–56) | 0.57 | 49 (34–57) | 40 (29–55) | 0.08 |
| Sex, male, no. (%) of patients | 112 (70) | 7 (54) | 0.23 | 52 (74) | 52 (66) | 0.26 | 8 (73) | 29 (64) | 0.29 |
| Cause of death, no. (%) of patients | 0.01 | 0.11 | 0.42 | ||||||
| HIBI | 75 (47) | 5 (38) | 35 (50) | 37 (45) | 55 (48) | 22 (49) | |||
| TBI | 38 (24) | 0 | 16 (23) | 19 (23) | 27 (24) | 9 (20) | |||
| CVA | 28 (18) | 7 (54) | 8 (11) | 20 (24) | 17 (15) | 11 (24) | |||
| Other | 19 (12) | 1 (8) | 11 (16) | 6 (23) | 14 (13) | 9 (20) | |||
| WLSM to death, min, median (IQR) | 21 (17–29) | 19 (15–40) | 0.70 | 20 (17–28) | 21 (17–31) | 0.50 | 20 (16–29) | 22 (18–28) | 0.38 |
| FWIT, min, median (IQR) | 26 (19–35) | 31 (21–49) | 0.55 | 27 (22–36) | 24 (18–31) | 0.15 | 25 (18–33) | 29 (23–36) | 0.06 |
| Cardiac arrest to perfusion, min, median (IQR) | 14 (12–17) | 15 (13–16) | 0.41 | 13 (12–17) | 14 (12–17) | 0.90 | 13 (12–16) | 15 (14–20) | < 0.001 |
| Heparin administration to death, min, median (IQR) | 14 (9–23) | NA | NA | 23 (17–29) | 10 (7–14) | < 0.001 | 13 (8.5–22.5) | 15 (10–26) | 0.15 |
| KDRI, median (IQR) | 1.03 (0.81–1.27) | 1.18 (0.92–1.32) | 0.25 | 1.03 (0.82–1.26) | 1.03 (0.80–1.33) | 0.94 | 1.06 (0.83–1.33) | 0.93 (0.80–1.20) | 0.12 |
CVA = cerebrovascular accident (subarachnoid hemorrhage, intracerebral hemorrhage or ischemic stroke); FWIT = functional warm ischemic time; HIBI = hypoxic–ischemic brain injury; KDRI = kidney donor risk index; IQR = interquartile range; TBI = traumatic brain injury; WLSM = withdrawal of life-sustaining measures.
↵* Heparin administration was considered early if it was before or concomitantly with WLSM, and it was considered delayed if it was administered after the onset of hypoxemia (oxygen saturation < 70%) or hypotension (systolic pressure < 60 mm Hg or mean arterial pressure < 50 mm Hg).
↵† Heparin dose was considered high if ≥ 300 units/kg and low if < 300 units/kg.