Characteristics of patients with autoimmune hepatitis at the time of liver transplantation, by era
| Characteristic | Era; no. (%) of patients* | p value | ||
|---|---|---|---|---|
| 2000–2005 n = 68 | 2006–2011 n = 68 | 2012–2018 n = 84 | ||
| Length of follow-up, median (Q1–Q4), yr | 14.6 (10.9–16.4) | 8.7 (7.5–11.2) | 2.5 (0.9–5.2) | — |
| Age of recipient, median (Q1–Q4), yr | ||||
| Overall | 53 (40–59) | 44 (27–57) | 47 (33–59) | 0.04 |
| Female | 53 (40–58) | 45 (27–57) | 47 (33–61) | 0.1 |
| Male | 53 (40–60) | 42 (28–58) | 44 (31–56) | 0.3 |
| Sex of recipient | 0.5 | |||
| Female | 50 (73.5) | 44 (64.7) | 59 (70.2) | |
| Male | 18 (26.5) | 24 (35.3) | 25 (29.8) | |
| Age of donor, median (Q1–Q4), yr | 45 (34–54) | 43 (30–53) | 41 (27–52) | 0.5 |
| Sex of donor | 0.4 | |||
| Female | 33 (52.4) | 36 (56.2) | 36 (44.4) | |
| Male | 30 (47.6) | 28 (43.8) | 45 (55.6) | |
| Missing | 5 (7.4) | 4 (5.9) | 3 (3.6) | |
| Graft type | 0.07 | |||
| DCD | 0 (0) | 3 (4.4) | 7 (8.3) | |
| NDD | 59 (86.8) | 52 (76.5) | 59 (70.2) | |
| LDLT | 9 (13.2) | 13 (19.1) | 18 (21.4) | |
| MELD score, median (Q1–Q4) | 16 (13–20) | 20 (15–27) | 24 (18–33) | < 0.001 |
| Creatinine level, median (Q1–Q4), μmol/L | 77 (59–97) | 82 (66–104) | 78 (64–98) | 0.5 |
| Bilirubin level, median (Q1–Q4), μmol/L | 64 (33–113) | 76 (44–314) | 92 (58–430) | 0.04 |
| INR, median (Q1–Q4) | 1.5 (1.2–1.8) | 1.7 (1.5–2.3) | 2.1 (1.6–3.0) | < 0.001 |
| Retransplantation | 4 (5.9) | 8 (11.8) | 6 (7.1) | — |
| Retransplantation in first year | 3 (4.4) | 3 (4.4) | 5 (6.0) | — |
DCD = donation after cardiac death; INR = international normalized ratio; LDLT = living donor liver transplantation; MELD = Model for End-stage Liver Disease; NDD = neurologic determination of death; Q = quartile.
↵* Except where noted otherwise.