Characteristics of patients with primary sclerosing cholangitis at the time of liver transplantation, by era
| Characteristic | Era; no. (%) of patients* | p value | ||
|---|---|---|---|---|
| 2000–2005 n = 123 | 2006–2011 n = 159 | 2012–2018 n = 207 | ||
| Length of follow-up, median (Q1–Q4), yr | 14.5 (10.4–17.0) | 8.5 (7.2–10.7) | 2.6 (1.3–4.9) | — |
| Age of recipient, median (Q1–Q4), yr | ||||
| Overall | 46 (36–53) | 43 (32–53) | 44 (35–54) | 0.3 |
| Female | 46 (34–52) | 41 (29–57) | 48 (37–56) | 0.2 |
| Male | 47 (36–54) | 43 (33–52) | 44 (35–53) | 0.5 |
| Sex of recipient | 0.2 | |||
| Female | 29 (23.6) | 42 (26.4) | 66 (31.9) | |
| Male | 94 (76.4) | 117 (73.6) | 141 (68.1) | |
| Age of donor, median (Q1–Q4), yr | 39 (25–52) | 43 (31–53) | 38 (28–53) | 0.4 |
| Sex of donor | 0.3 | |||
| Female | 45 (37.8) | 72 (46.8) | 83 (40.5) | |
| Male | 74 (62.2) | 82 (53.2) | 122 (59.5) | |
| Missing | 4 (3.2) | 5 (3.1) | 2 (1.0) | |
| Donor type | ||||
| DCD | 0 (0) | 6 (3.8) | 13 (6.3) | 0.001 |
| NDD | 100 (81.3) | 105 (66.0) | 126 (60.9) | |
| LDLT | 23 (18.7) | 48 (30.2) | 68 (32.8) | |
| MELD score, median (Q1–Q4) | 17 (11–22) | 20 (14–27) | 18 (14–23) | 0.01 |
| Creatinine level, median (Q1–Q4), μmol/L | 76 (65–102) | 73 (63–108) | 71 (54–85) | 0.04 |
| Bilirubin level, median (Q1–Q4), μmol/L | 86 (32–196) | 170 (52–377) | 103 (61–268) | 0.004 |
| INR, median (Q1–Q4) | 1.3 (1.1–1.7) | 1.4 (1.2–1.9) | 1.4 (1.2–1.7) | 0.02 |
| Retransplantation | 13 (10.6) | 18 (11.3) | 19 (9.2) | — |
| Retransplantation in first year | 4 (3.2) | 8 (5.0) | 12 (5.8) | — |
DCD = donation after cardiac death; INR = international normalized ratio; LDLT = living donor liver transplantation; MELD = Model for End-stage Liver Disease; NDD = neurologic determination of death; Q = quartile.
↵* Except where noted otherwise.