Characteristics of patients with primary biliary cholangitis at the time of liver transplantation, by era
| Characteristic | Era; no. (%) of patients* | p value | ||
|---|---|---|---|---|
| 2000–2005 n = 116 | 2006–2011 n = 108 | 2012–2018 n = 117 | ||
| Length of follow-up, median (Q1–Q4), yr | 13.6 (5.0–16.7) | 9.1 (7.3–11.2) | 2.9 (1.3–4.6) | — |
| Age of recipient, median (Q1–Q4), yr | ||||
| Overall | 53 (46–60) | 58 (49–63) | 56 (48–61) | 0.01 |
| Female | 53 (46–60) | 56 (48–62) | 56 (47–61) | 0.09 |
| Male | 53 (44–62) | 61 (54–66) | 57 (54–64) | 0.03 |
| Sex of recipient | 0.6 | |||
| Female | 91 (78.4) | 88 (81.5) | 98 (83.8) | |
| Male | 25 (21.6) | 20 (18.5) | 19 (16.2) | |
| Age of donor, median (Q1–Q4), | 42 (25–53) | 47 (29–57) | 38 (28–56) | 0.2 |
| Sex of donor | 0.2 | |||
| Female | 55 (48.7) | 56 (51.8) | 69 (59.5) | |
| Male | 58 (51.3) | 52 (48.1) | 47 (40.5) | |
| Missing | 3 (2.6) | 0 (0) | 1 (0.8) | |
| Donor type | < 0.001 | |||
| DCD | 0 (0) | 0 (0) | 13 (11.1) | |
| NDD | 94 (81.0) | 78 (72.2) | 71 (60.7) | |
| LDLT | 22 (19.0) | 30 (27.8) | 33 (28.2) | |
| MELD score, median (Q1–Q4) | 17 (11–22) | 18 (15–25) | 20 (16–26) | 0.004 |
| Creatinine level, median (Q1–Q4), μmol/L | 77 (60–99) | 73 (56–107) | 84 (56–120) | 0.7 |
| Bilirubin level, median (Q1–Q4), μmol/L | 75 (34–217) | 97 (42–272) | 105 (67–327) | 0.06 |
| INR, median (Q1–Q4) | 1.3 (1.2–1.7) | 1.4 (1.2–1.9) | 1.5 (1.3–2.0) | 0.002 |
| Retransplantation | 11 (9.5) | 8 (7.4) | 5 (4.3) | — |
| Retransplantation in first year | 6 (5.2) | 4 (3.7) | 3 (2.6) | — |
DCD = donation after cardiac death; INR = international normalized ratio; LDLT = living donor liver transplantation; MELD = Model for End-stage Liver Disease; NDD = neurologic determination of death; Q = quartile.
↵* Except where noted otherwise.