Clinicopathologic characteristics of patients with adenocarcinoma of the upper gastrointestinal tract who underwent gastrectomy or esophagectomy with extended (D2) lymphadenectomy
| Characteristic | No. (%) of patients* | p value | |
|---|---|---|---|
| pMMR n = 198 | dMMR n = 28 | ||
| Age, mean ± SD, yr | 67 ± 11 | 73 ± 14 | 0.02 |
| Male sex | 155 (78.3) | 20 (71.4) | 0.6 |
| Tumour location | |||
| Distal esophagus | 63 (31.8) | 0 (0.0) | 0.001 |
| Gastroesophageal junction | 83 (41.9) | 15 (53.6) | |
| Subcardial | 52 (26.3) | 13 (46.4) | |
| Clinical stage | |||
| Early (I–II) | 53 (26.8) | 8 (28.6) | 0.9 |
| Locally advanced (III) | 145 (73.2) | 20 (71.4) | |
| Neoadjuvant therapy | |||
| None | 61 (30.8) | 12 (42.9) | 0.4 |
| Chemotherapy | 131 (66.2) | 15 (53.6) | |
| Chemoradiotherapy | 6 (3.0) | 1 (3.6) | |
| Tumour grade | |||
| Well differentiated | 8 (4.0) | 3 (10.7) | 0.2 |
| Moderately differentiated | 78 (39.4) | 13 (46.4) | |
| Poorly differentiated | 112 (56.6) | 12 (42.9) | |
| Pathologic stage | |||
| I | 25 (12.6) | 7 (25.0) | 0.01 |
| II | 29 (14.6) | 9 (32.1) | |
| III | 113 (57.1) | 11 (39.3) | |
| IV | 31 (15.7) | 1 (3.6) | |
| No. of positive lymph nodes, median (IQR) | 3 (1–8) | 1 (0–5) | 0.02 |
| Lymph node status | |||
| N0 | 41 (20.7) | 13 (46.4) | 0.03 |
| N1 (1–2) | 45 (22.7) | 4 (14.3) | |
| N2 (3–6) | 51 (25.8) | 5 (17.9) | |
| N3 (≥ 7) | 61 (30.8) | 6 (21.4) | |
| Survival analysis | |||
| 90-day mortality | 15 (7.6) | 3 (10.7) | 0.3 |
| Overall survival, median (95% CI), yr† | 2.4 (1.9–3.0) | 5.8 (3.4–8.2) | 0.03 |