Table 3

Perioperative surgical outcomes for patients who received or did not receive a vitamin K antagonist

StudyAdmission INR, mean ± SD (range)Time to surgery, mean ± SD (range), hLength of stay, mean ± SD (range), dDeep vein thrombosis, no. of patientsPulmonary embolism, no. of patientsPostoperative venous thromboembolism, no. of patients
Before protocolAfter protocolBefore protocolAfter protocolControlBefore protocolAfter protocolControlBefore protocolAfter protocolControlBefore protocolAfter protocolControlBefore protocolAfter protocolControl
Schuetze et al., (29) 2019—NR—10.0 (4.3–23.8)8.2 (1.2–23.9)—NRNR—NRNR—NRNR—NRNR
Mattisson et al., (15) 2018—2.5 (0.6)—16.0 (4.8)14.0 (5.6)—4.9 (2.6)4.9 (2.6)—00—00—00
Moores et al., (29) 20192.6 (0.9)2.5 (1.0)70.4 (61.9)46.0 (38.0)—17.3 (14.2)22.4 (39.7)—NRNR—NRNR—NRNR—
Ng et al., (28) 2019—3.1 (1.5)32.5 (23.2)——11 (2–62)*——1——0——1—
Diament et al., (21) 2015—2.5 (1.5–4.4)53.7 (1.7–128.0)37.6 (14.7–71.8)28.4 (5.0–286.4)16.7 (2.0–65.0)15.8 (8.0–44.0)14.1 (2.0–67.0)—0——0——0—
Ahmed et al., (23) 20143.4 (3.6)3.3 (2.6)74.7 (43.7)36.9 (12.6)—24.4 (14.8)22.1 (14.1)—NRNR—NRNR—NRNR—
Buecking et al., (24) 2014
 PCCs†2.0 (0.7)2.3 (0.6)28.0 (15.0)21.0 (10.0)—NRNR—00—00—00—
 Vitamin K ± PCCs—2.1 (0.7)27.0 (14.0)16.0 (12.0)—15.0 (6.0)13.0 (6.0)—01—02—03
Tal et al., (30) 20132.7 (0.7)2.4 (0.7)122.4 (58.1)63.4 (26.9)16.6 (19.9)13.2 (4.9)9.4 (1.9)7.3 (2.4)NRNRNRNRNRNRNRNRNR
Ashouri et al., (22) 2011NRNR74.7 (43.7)36.9 (12.6)—24.4 (14.8)22.1 (14.1)—NRNR—NRNR—NRNR—
Vitale et al., (31) 20111.9 (0.7)2.6 (1.1)163.2 (45.6)67.2 (31.2)—NRNR—02—01—03—
Bhatia et al., (25) 20102.9 (1.5–6.5)2.5 (1.9–7.1)9138—NRNR—NRNR—NRNR—NRNR—
Weighted total, no. (%)2.62.671.435.519.619.215.311.50 (0.0)3 (0.9)1 (0.2)0 (0.0)1 (0.3)2 (0.5)0 (0.0)4 (1.3)3 (0.7)

  • INR = International Normalized Ratio; NR = not recorded; PCC = prothrombin complex concentrate; SD = standard deviation.

  • ↵* Reported as median and range (not included in weighted total calculation).

  • ↵† Not included in total calculations as it was a subgroup analysis.