Table 4

Perioperative surgical outcomes for patients who received or did not receive a direct oral anticoagulant

Study	Time to surgery, mean ± SD (range), h		Surgical duration, mean ± SD,^* h		Change in postoperative hemoglobin level, mean ± SD (range), g/L		Change in postoperative hemoglobin level, mean, %		pRBC transfusion, no. of patients		30-day mortality, no. of patients

	Control	DOAC	Control	DOAC	Control	DOAC	Control	DOAC	Control	DOAC	Control	DOAC
Schermann et al., (20) 2019

CRIF	31.2 ± 22.2	40.2 ± 26.9	110.7 ± 48.9	—	NR	NR	24.0	22.6	77	5	43	4

HA	36.3 ± 25.8	42.3 ± 27.3	126.2 ± 39.8	—	NR	NR	21.0	21.7	36	3	30	2

Schuetze et al., (29) 2019	8.2 (1.3–23.9)	9.5 (2.3–24.0)	NR	NR	NR	NR	NR	NR	24	20	NR	NR

Franklin et al., (14) 2018	21.4 ± 12.4	28.9 ± 11.8	93.5 ± 44.2	82.7 ± 37.9	30 ± 2.0	32 ± 1.4	NR	NR	6	25	12	1

Mullins et al., (27) 2018	19 (3–44)^*	19 (7–64)^*	NR	NR	23 (1–47)	23 (0–49)	NR	NR	6	11	5	1

Weighted total, no. (%)	30.2^†	29.3^†	114.8	120.9	29.2	29.3	23.0	22.3	149 (8.6)	64 (29.1)	90 (5.6)	8 (4.7)

CRIF = closed reduction internal fixation; DOAC = direct oral anticoagulant; HA = hemiarthroplasty; NR = not recorded; pRBC = packed red blood cells; SD = standard deviation.
↵* Reported as median and range.
↵† Weighted mean does not include the study by Mullins and colleagues. (27)