Table 3

Tumour characteristics of patients with a positive nipple margin (n = 10)

PatientTumour histologyTumour size on imaging, cmTumour size on pathology, cmClinical distance to nipple, cmRadiological distance to nipple, cmNAT or upfront surgeryIncision for NSMManagement of positive nipple biopsyAdjuvant therapy
1DCIS1.53.2Not palpable3SurgeryInframammary foldNAC excisionNone
2DCIS3.80*Unknown0.8SurgeryInframammary foldObservationNone
3Invasive cancer4.03.5Not palpable5.5SurgeryRadialNAC excisionEndocrine
4Invasive cancer0.11.7NANASurgeryInframammary foldNAC excisionChemotherapy, RT and endocrine
5Invasive cancer1.52.254SurgeryInframammary foldNAC excisionChemotherapy, RT and endocrine
6Invasive cancer74.055NATInframammary foldNAC excisionRT and endocrine
7Invasive cancer31.2Unknown6NATInframammary foldNAC excisionRT and endocrine
8Invasive cancer0.91.677SurgeryRadialNAC excisionEndocrine
9DCIS98.025SurgeryCircumareolar with lateral extensionObservationNone
10DCIS4.14.00.52SurgeryInframammary foldObservationChemotherapy, RT and endocrine
  • DCIS = ductal carcinoma in situ; NA = not applicable; NAC = nipple-areolar complex; NAT = neoadjuvant therapy; NSM = nipple sparing mastectomy; RT = radiation therapy.

  • * Multifocal DCIS.

  • Patient had a normal mammogram and ultrasonography performed, but had a palpable mass in the axillary tail of left breast, that was excised and revealed invasive lobular cancer with positive margins. The patient had bilateral magnetic resonance imaging (normal), but elected to proceed with NSM.