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LigaSure™ compared with ligatures and endoclips in experimental appendectomy: how safe is it?

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Abstract

Purpose

The present study aims to compare strength, healing, and inflammation of appendiceal stumps closed by LigaSure Precise™ (Valleylab, Boulder, CO, USA) device, ligatures using polyglactin 910 (Vicryl, Ethicon, Edinburgh, UK) and endoclips (Ligaclip ERCA, Ethicon, OH, USA), and operation time (OT) in experimental appendectomy.

Methods

Forty-eight Sprague–Dawley rats were divided into two (Group A and B). Each group was further subdivided into three subgroups (AS, AC, AL, BS, BC, BL) containing eight rats. Appendectomy was performed and stump was closed by ligatures in S, by endoclips in C and by LigaSure™ in L subgroups. OT was recorded. In Group A, cecum bursting pressures (BP) were determined instantly after the operation. In Group B, BP, histological evaluations, and measurements of collagen contents estimated by the tissue hydroxyproline (HPL) level were made on the seventh postoperative day. Statistical analyses were performed with Kruskal–Wallis test and Mann–Whitney U test. P value was considered significant at less than 0.05.

Results

BPs of subgroups were comparable on postoperative immediate period and day 7. HPLs and OTs were significantly better in L subgroups. BL had the least inflammation.

Conclusion

Better healing, less inflammation, shorter OT, and equal strength achieved with LigaSure™ device comparing with polyglactin 910 ties and endoclips in experimental appendectomy is encouraging.

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Conflict of interest statement

The authors declare that, they do not have a financial relationship with any organization, and that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pediatric Surgery, Medical Faculty, Kocaeli University, Kocaeli, Turkey

    Levent Elemen, Melih Tugay & Alper Akay

  2. Department of Histology and Embryology, Medical Faculty, Kocaeli University, Kocaeli, Turkey

    Yusufhan Yazir & Süreyya Ceylan

  3. Department of Biochemistry, Cerrahpaşa Medical Faculty, İstanbul University, Istanbul, Turkey

    Seval Aydin & Karolin Yanar

Authors
  1. Levent Elemen
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  2. Yusufhan Yazir
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  3. Melih Tugay
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  4. Alper Akay
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  7. Süreyya Ceylan
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Correspondence to Levent Elemen.

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Elemen, L., Yazir, Y., Tugay, M. et al. LigaSure™ compared with ligatures and endoclips in experimental appendectomy: how safe is it?. Pediatr Surg Int 26, 539–545 (2010). https://doi.org/10.1007/s00383-010-2557-x

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  • DOI: https://doi.org/10.1007/s00383-010-2557-x

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