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Randomized trial of health-related quality of life after open and laparoscopic surgery for colon cancer

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Abstract

Background

Randomized controlled trials (RCTs) have reported improved or unchanged three-year survival following laparoscopic colon resection (LCR) for colon cancer compared with that following open resection (OCR). The aim of this study was to determine health-related quality of life (HRQL) in patients randomized to laparoscopic or open resection for colon cancer.

Methods

In total, 285 patients (130 LCR, 155 OCR) from seven Swedish centers were included. HRQL was assessed preoperatively and at 2, 4, and 12 weeks postoperatively with the EQ-5D and EORTC QLQ-C30 instruments.

Results

The LCR patients did significantly better on the social function component of the EORTC QLQ-C30 at two and four weeks and on the role function component at two weeks.

Conclusion

Laparoscopic resection for colon cancer improved quality of life during the first postoperative month.

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Acknowledgments

This work was supported by grants from the Swedish Cancer Foundation (grant number 4287-B01-03XCC), the County Council of Stockholm, Assar Gabrielsson’s Foundation for Clinical Research, Jubileumskliniken Research Foundation, Sahlgrenska University Hospital, and the Swedish Society of Medicine. Special thanks to Yngve Raab and Lars Påhlman (University Hospital, Uppsala), Johan Dalén and Ingrid Svedberg (St. Göran Hospital ,Stockholm), Karin Strigård and Gunilla Walldin (Karolinska University Hospital, Huddinge), Anders Kald and P.O. Nyström (Linköping University Hospital, Linköping), Stefan Skullman (SKAS/Kärnsjukhuset, Skövde), Göran Kurlberg (Sahlgrenska University Hospital, Göteborg), and Ulf Kressner (NU sjukvården/Uddevalla Hospital, Uddevalla) for contributing patients to the COLOR trial and to this study. The authors are grateful to Jaap Bonjer, MD, Ruben Veldkamp, MD, and Esther Kuhry, MD, Erasmus Medical Centre, Rotterdam, the Netherlands for providing necessary data from the COLOR trial files and to Harriet Törnqvist for meticulous technical support throughout the study.

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Authors and Affiliations

  1. Department of Surgery, Karolinska Institutet at Karolinska University Hospital Huddinge, K53, SE-141 86, Stockholm, Sweden

    Martin Janson

  2. Department of Surgery, Institute of Surgical Sciences, Göteborg University, Sahlgrenska University Hospital, SE-413 45, Göteborg, Sweden

    Elisabet Lindholm & Eva Haglind

  3. Department of Molecular Medicine and Surgery, Karolinska Institutet at Karolinska University Hospital Solna, SE-171 76, Stockholm, Sweden

    Bo Anderberg

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  1. Martin Janson
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Correspondence to Martin Janson.

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Janson, M., Lindholm, E., Anderberg, B. et al. Randomized trial of health-related quality of life after open and laparoscopic surgery for colon cancer. Surg Endosc 21, 747–753 (2007). https://doi.org/10.1007/s00464-007-9217-9

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  • DOI: https://doi.org/10.1007/s00464-007-9217-9

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