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Barrett’s Columnar-Lined Oesophagus: Demographic and Lifestyle Associations and Adenocarcinoma Risk

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Abstract

Objectives Lifestyle and demographic risk factors for the development of oesophageal adenocarcinoma developing from columnar-lined oesophagus are not well defined. Methods Demographic and lifestyle factors, endoscopy and histology reports were extracted from 1,761 subjects from seven UK centres. The associations of columnar-lined oesophagus with demographic and lifestyle factors and the development of adenocarcinoma were examined. Results 5.5% of patients had prevalent adenocarcinoma (more common in males, older patients, patients diagnosed earlier in the cohort and current or recent smokers). Adenocarcinoma incidence was 23 patients in 3,912 years or 0.59% per annum. Only increased age at diagnosis correlated with an increased risk of incident adenocarcinoma. There was no association with obesity or alcohol history. Conclusions Oesophageal adenocarcinoma occurs more commonly in older patients and is more frequent in males than females. Once columnar-lined oesophagus had been diagnosed, there were no other demographic or lifestyle factors which were predictive of the development of incident adenocarcinoma in this cohort.

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Acknowledgements

We are indebted to the registrants and registering centres (see Appendix 1) who made this study possible and to Dr. R. Fitzgerald for assistance in the project design and manuscript preparation. We are grateful to the following for financial support: the Barrett’s Oesophagus Foundation, the Wexham Gastrointestinal Trust, the Childwick Trust, the R. L. St. J. Harmsworth Memorial Research Fund and the David and Frederick Barclay Foundation.

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Authors and Affiliations

  1. UK National Barrett’s Oesophagus Registry (UKBOR), Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St., London, NW3 2PF, UK

    P. A. C. Gatenby, C. P. J. Caygill, J. R. Ramus & A. Watson

  2. Health Protection Agency, 61 Colindale Avenue, London, NW9 5EQ, UK

    A. Charlett

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  1. P. A. C. Gatenby
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  2. C. P. J. Caygill
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  3. J. R. Ramus
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  4. A. Charlett
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  5. A. Watson
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Correspondence to P. A. C. Gatenby.

Appendix 1—collaborating centres

Appendix 1—collaborating centres

Bishop Auckland General Hospital

Dr. M. Bateson

Hemel Hempstead Hospital

Dr. I. Barrison

Mr. G. Sagor

Landough Hospital, Cardiff

Dr. P. Smith

Dr. J. Green

Ninewells Hospital, Dundee

Dr. D. Johnston

Mrs. M. Lopez

Royal Free Hospital, London

Dr. O. Epstein

Rotherham General Hospital

Prof. K. Bardhan

Mrs. C. Royston

Wexham Park Hospital, Slough

Dr. S. Levi

Mrs. B. Johnston

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Gatenby, P.A.C., Caygill, C.P.J., Ramus, J.R. et al. Barrett’s Columnar-Lined Oesophagus: Demographic and Lifestyle Associations and Adenocarcinoma Risk. Dig Dis Sci 53, 1175–1185 (2008). https://doi.org/10.1007/s10620-007-0023-y

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