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Obesity Is Associated with an Increased Prevalence of Advanced Adenomatous Colon Polyps in a Male Veteran Population

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Abstract

Obesity has been associated with an increased risk for colonic adenomatous polyps (APs) and colorectal cancers, but the influence of obesity on the development of advanced APs is not clear. The purpose of this study is to determine the influence of obesity on the prevalence of advanced APs in a male veteran population. We performed a retrospective study of patients (n = 2,903) with histologically confirmed APs on an index colonoscopy. APs were evaluated for advanced features (size ≥1 cm in diameter and/or a villous component and/or high grade dysplasia). Patients were categorized as: normal weight (BMI >18.5 and <25), overweight (BMI ≥25 and <30), and obese (BMI ≥30). An association between clinical factors and advanced APs was sought by Kruskal–Wallis test and Pearson Chi-square. Multiple logistic regression analysis was used to determine independent predictors for advanced APs. We identified 2,903 male patients with APs (mean age 64 + 1.1(SE) years; 770 (27%) normal weight, 1,029 (35%) overweight, 1,104 (38%) obese. By univariate analysis, obese patients had a greater prevalence of advanced APs than the overweight and normal weight patients (28 vs. 23 vs. 24%, p = 0.025). Multiple logistic regression analysis confirmed the association of obesity and advanced APs (OR = 1.01, CI = 1–1.02, p = 0.04). For every one-unit increase in BMI above 30, there was a corresponding 1% increase in the frequency of finding advanced APs. Obesity in male veteran patients is associated with the finding of advanced APs on colonoscopy. We speculate that obesity may increase the risk for CRC by promoting the development of advanced APs.

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Abbreviations

CRC:

Colorectal cancer

AP:

Adenomatous polyps

HMG-CoA:

3-Hydroxy-3-methyl glutaryl coenzyme A

NSAIDs:

Non-steroidal anti-inflammatory drugs

BMI:

Body mass index

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Acknowledgments

The current study was performed without any grant support.

Conflict of interest statement

The authors attest that they have no commercial associations (e.g., equity ownership or interest, consultancy, patent and licensing agreement, or institutional and corporate associations) that might be a conflict of interest in relation to the submitted manuscript.

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Authors and Affiliations

  1. Department of Internal Medicine, Dallas Veterans Affairs Medical Center, 4500 S. Lancaster Road (111B1), Dallas, TX, 75216, USA

    Ali Siddiqui, Helene N. Pena Sahdala, Hector E. Nazario, Amar Mahgoub, Mahir Patel & Stuart Spechler

  2. University of Texas Southwestern Medical School, Dallas, TX, USA

    Ali Siddiqui, Helene N. Pena Sahdala, Hector E. Nazario, Amar Mahgoub, Mahir Patel & Stuart Spechler

  3. The Dallas Veterans Affairs Research Corporation, Dallas, TX, USA

    Daisha Cipher

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  1. Ali Siddiqui
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Correspondence to Ali Siddiqui.

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Siddiqui, A., Pena Sahdala, H.N., Nazario, H.E. et al. Obesity Is Associated with an Increased Prevalence of Advanced Adenomatous Colon Polyps in a Male Veteran Population. Dig Dis Sci 54, 1560–1564 (2009). https://doi.org/10.1007/s10620-009-0811-7

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  • DOI: https://doi.org/10.1007/s10620-009-0811-7

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