NADPH-diaphorase histochemistry provides evidence for a bilateral, somatotopically inappropriate response to unilateral hindpaw inflammation in the rat
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2023, IBRO Neuroscience ReportsNADPH-d/NOS reactivity in the lumbar dorsal horn of congenitally hypothyroid pups before and after formalin pain induction
2009, International Journal of Developmental NeuroscienceCitation Excerpt :It has been presumed that there is remarkable correlation between NADPH-d and NOS containing neurons in the CNS (Dawson et al., 1991; Hope et al., 1991). However, several studies have been shown that NADPH-d histochemistry and NOS immunohistochemistry do not necessarily label the same population of neurons (Herdegen et al., 1994; Lukácová et al., 1999; Traub et al., 1994a,b). Indeed, NOS is not the only enzyme which possessing NADPH-d activity and it represents only a fraction of the total NADPH-d activity (Tracey et al., 1993).
Neurogenic Mechanisms in Arthritis
2009, NeuroImmune BiologyCitation Excerpt :Many other molecules expressed in the spinal cord show bilaterally altered expression levels or activation. These molecules have varied functions but include second messenger molecules such as NADPH-diaphorase [119] (thought to equate with nitric oxide synthase expression), cyclooxygenase-2 [120], protein kinase C [121], and CREB (cAMP response element binding protein) [122], proinflammatory molecules such as tumor necrosis factor α and interleukin-1 [123], and neurotransmitter receptors N-methyl-D aspartic acid (NMDA receptors) [124]. Alterations in expression of such molecules could be interpreted as being indicative of contralateral spinal neuronal activation.
Effects of a chronic myositis on structural and functional features of spinal astrocytes in the rat
2004, Neuroscience LettersPeripheral inflammation increases phosphoinositide activity in the rat dorsal horn
2004, Brain ResearchCitation Excerpt :Indeed, evidence for bilateral effects of pain include the distribution of changes in levels of c-fos[20], [14C]2-deoxyglucose accumulation [28], membrane-bound PKC [21], and NADPH–diaphorase activity [33]. Similarly, while the somatotopy of afferent projections from hindlimb predicts involvement of medial dorsal horn, stronger effects are sometimes found laterally [28,33], as described here. The present results contribute to an emerging view that persistent nociception may recruit spinal cord involvement well beyond the terminal field of the nociceptive afferents that were initially stimulated [22].
Glucocorticoid effects on Fos immunoreactivity and NADPH-diaphorase histochemical staining following spinal cord injury
2001, Brain ResearchCitation Excerpt :These areas contain a moderate constitutive level of NADPH-d activity/NOS immunoreactivity [8,38,59]. Strong nociceptive input derived from spinal cord hemisection, root avulsion, hindpaw inflammation and axotomy produce robust increases in NADPH-d activity and/or NOS immunoreactivity as was the case with SCI [8,51,58,59,64]. However, these stimuli caused at the most a transient increase of a few hours in the enzyme, followed by a decrease persisting over many days [8].