Research reportChanges in preprotachykinin mRNA expression and substance P levels in dorsal root ganglia of monoarthritic rats: comparison with changes in synovial substance P levels
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Cited by (31)
Peripheral scaffolding and signaling pathways in inflammatory pain
2015, Progress in Molecular Biology and Translational ScienceCitation Excerpt :NK1R is expressed in sensory afferent endings,35 immune cells,36 and both epithelial and larger blood vessels,37 leading some to categorize the peptide as a broadly efficacious neuropathic inflammatory mediator. Furthermore, due to increased expression of substance P and NK1R within and adjacent to inflamed skeletal joints,38,39 many studies suggest that substance P may be an important modulator in rheumatoid arthritis. Many types of glutamate receptors, both ionotropic and metabotropic, are expressed throughout the body.
Gait analysis and pain response of two rodent models of osteoarthritis
2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Neuropeptide synthesis is enhanced during OA progression and spinal cord production of these peptides is an important factor modifying the process of signal transmission and modulation of central mechanisms of pain (Niissalo et al., 2002). Substance P and CGRP, coexisting in small-diameter afferent fibres, have been found to directly participate in the injury-induced neuroplasticity changes in arthritis (Ahmed et al., 1995; Garrett et al., 1995; Keeble and Brain, 2004; Bird et al., 2006). The concentrations of both neuropeptides were increased in both OA models suggesting that excitatory neurotransmission initiated long term changes at the central level.
Joint Distraction Magnitude Is Associated With Different Behavioral Outcomes and Substance P Levels for Cervical Facet Joint Loading in the Rat
2009, Journal of PainCitation Excerpt :Interestingly, SP mRNA increases temporally in the DRG for a nonpainful joint distraction, but remains unchanged over time for a painful distraction (Fig 2A). Other studies have reported that neuropeptide (CGRP) and preprotachykinin A (an SP precursor) mRNA are increased in the DRG in rat models of joint inflammation,8,22 which could suggest that SP mRNA may likely also be increased in the DRG for cases of joint inflammation. However, the initial mode of injury in the current model was mechanical joint loading, producing SP mRNA in the DRG that was observed only for nonpainful distractions and not for painful cases (Fig 2A).
A role for substance P in arthritis?
2004, Neuroscience Letters