Original contributionEvidence that the large loss of glutathione observed in ischemia/reperfusion of the small intestine is not due to oxidation to glutathione disulfide
References (44)
- et al.
Effect of oxygen concentration on the formation of malondialdehyde-like material in a model of tissue ischemia and reoxygenation
Free Radic. Biol. Med.
(1989) - et al.
Involvement of hydrogen peroxide and hydroxyl radical in the ‘oxygen paradox’: Reduction of creatine kinase release by catalase, allopurinol or deferoxamine, but not by superoxide dismutase
J. Mol. Cell. Cardiol.
(1985) Reperfusion-induced arrhythmias: Do free radicals play a critical role
Free Radic. Biol. Med.
(1988)- et al.
Modification of the xanthine-converting enzyme of perfused rat heart during ischemia and oxidative stress
Free Radic. Biol. Med.
(1988) - et al.
Biochemical changes in the intestine associated with anoxia and reoxygenation: In vivo and in vitro studies
Free Radic. Biol. Med.
(1986) - et al.
Xanthine oxidase is not a source of free radicals in the ischemic rabbit heart
J. Mol. Cell. Cardiol.
(1987) - et al.
The importance of free radicals and catalytic metal ions in human disease
Mol. Aspects Med.
(1985) - et al.
Ferritin and superoxide-dependent lipid peroxidation
J. Biol. Chem.
(1985) - et al.
Cardiac arrest and resuscitation: Brain iron delocalization during reperfusion
Ann. Emerg. Med.
(1985) - et al.
Natural course of iron delocalization and lipid peroxidation during the first eight hours following a 15-minute cardiac arrest in dogs
Ann. Emerg. Med.
(1987)
Superoxide dismutase: Rationale for use in reperfusion injury and inflammation
J. Free Radic. Biol. Med.
Hepatocellular oxidant stress following intestinal ischemia-reperfusion injury
J. Surg. Res.
Oxidation and release of glutathione from myocardium during early reperfusion
Free Radic. Biol. Med.
High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives
Methods Enzymol.
Oxygen free radicals and glutathione in hepatic ischemia/reperfusion injury
J. Surg. Res.
Methods for the selective modification of glutathione metabolism and study of glutathione transport
Methods Enzymol.
Arterial levels of oxidized glutathione (GSSG) reflect oxidant stress in vivo
J. Surg. Res.
Detection of oxygen radicals during reperfusion of intestinal cells in vitro
Free Radic. Biol. Med.
Mechanisms of oxidant-mediated microvascular injury followng reperfusion of the ischemic intestine
Basic Life Sci.
Purine nucleoside phosphorylase: A new marker for free oxygen radical injury to the endothelial cell
Hepatology
Oxygen-derived free radicals in postichemic tissue injury
N. Engl. J. Med.
Enhancement of recovery of myocardial function by oxygen free-radical scabengers after Reversible Regional Ischemia
Circulation
Cited by (37)
Protective effects of green tea on intestinal ischemia-reperfusion injury
2011, NutritionCitation Excerpt :It is interesting to note that although there was a mild to moderate expression of GPx in the intestinal mucosa of control sham I/R animals, the expression of GPx was negative in group I (I/R) and group II (green tea + I/R) animals. Our results are in agreement with the studies of Gibson et al. [31] who showed a large loss of glutathione in the small intestine of rats after I/R. Green tea, red wine, cocoa, olive oil, soya beans, and turmeric contain high concentrations of polyphenols, which have strong antioxidant properties.
Glutathione synthesis in intestinal ischaemia-reperfusion injury: effects of moderate hypothermia
2009, Journal of Pediatric SurgeryCitation Excerpt :The actions of these deleterious reactive species can be prevented by antioxidants, either those occurring naturally such as glutathione (GSH) or powerful xenobiotic antioxidants such as FeTMPyP [1,3]. Glutathione is a particularly important intracellular antioxidant that has been shown to have dramatically decreased levels in the intestine after intestinal I/R [2,4,5]. We have shown that hypothermia prevents liver bioenergetic failure and mortality during experimental intestinal I/R injury [6] and that this benefit persists even when hypothermia is applied at the time of reperfusion [7].
Total glutathione is not decreased in infants with necrotizing enterocolitis
2005, Journal of Pediatric SurgeryReduced glutathione oxidation ratio and 8 ohdG accumulation by mild ischemic pretreatment
2000, Brain ResearchCitation Excerpt :A representative HPLC chromatogram obtained from NEM-pretreated samples presented in the current study clearly demonstrated that a special care needs to be taken to correct for the artifactual oxidation of glutathione. It is also conceivable that GSH can decrease independently of GSSG as suggested in the rat intestine ischemia model [20]. Since changes in the total glutathione levels as well as its redox states contribute to the glutathione oxidation ratio, the degree of the glutathione oxidation ratio was employed as a measure of the ischemia-induced oxidative stress in the current study.